A0A093UPI7 · A0A093UPI7_TALMA

Function

function

Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular Function5-aminolevulinate synthase activity
Molecular Functionpyridoxal phosphate binding
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-aminolevulinate synthase
  • EC number
  • Alternative names
    • 5-aminolevulinic acid synthase
    • Delta-ALA synthase
    • Delta-aminolevulinate synthase

Gene names

    • ORF names
      GQ26_0530400

Organism names

  • Taxonomic identifier
  • Strain
    • PM1
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Talaromyces

Accessions

  • Primary accession
    A0A093UPI7

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region54-107Disordered
Compositional bias82-102Pro residues
Domain152-514Aminotransferase class I/classII large

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    613
  • Mass (Da)
    66,465
  • Last updated
    2014-11-26 v1
  • Checksum
    685EA18459E45B6C
MSNLQVIARRCPVMSKALAVQSSRLASKNFTTTACGIGATNKFRTFEKVSRRPLHTTAGNGASVEVGGTYEKGSRLHPQPPMDAGKPAPRKPEVPLAGPHPQAPATPKFDYEAFYKNELDKKHKDKSYRYFNNINRLAKEFPRAHMAAAEEKVTVWCSNDYLGMGRNREVLKSMHQTLENYGAGAGGTRNISGHNKHAVQLEGTLAKLHHKEAALVFSSCYVANDATLATLGSKLPDCVILSDSLNHASMIQGIRHSGAKKMVFKHNDMVDLETKLASLPAEVPKIIAFESVYSMCGSIAPIEKICDLADKYGAITFLDEVHAVGMYGPHGAGVAEHLDYDIYASQDTANPISTKDTIMDRIDIITGTLGKAYGCVGGYIAGSSKLVDTIRSLAPGFIFTTSLPPAIMAGANSAIEYQSRYSRDRTLQQLHTMAVKDAFKEIDIPVIPNPSHIVPLLVGDAELAKQASDMLLENHGIYVQAINYPTVPRGEERLRITPTPGHTKQYRNELVQAVNSVWNELGLKRTSEWKAQGGFVGVGVEGVEEQNMPIWENAQLGLKENESVEDAVNRELKEHALEEQALLAEAVQSMRTGGTTVNAAGFASVGTAVGVAA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias82-102Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JPOX01000053
EMBL· GenBank· DDBJ
KFX41845.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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