A0A093UPI7 · A0A093UPI7_TALMA
- Protein5-aminolevulinate synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids613 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
Catalytic activity
- succinyl-CoA + glycine + H+ = 5-aminolevulinate + CO2 + CoA
Cofactor
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Molecular Function | 5-aminolevulinate synthase activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-aminolevulinate synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Talaromyces
Accessions
- Primary accessionA0A093UPI7
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 54-107 | Disordered | ||||
Sequence: LHTTAGNGASVEVGGTYEKGSRLHPQPPMDAGKPAPRKPEVPLAGPHPQAPATP | ||||||
Compositional bias | 82-102 | Pro residues | ||||
Sequence: MDAGKPAPRKPEVPLAGPHPQ | ||||||
Domain | 152-514 | Aminotransferase class I/classII large | ||||
Sequence: KVTVWCSNDYLGMGRNREVLKSMHQTLENYGAGAGGTRNISGHNKHAVQLEGTLAKLHHKEAALVFSSCYVANDATLATLGSKLPDCVILSDSLNHASMIQGIRHSGAKKMVFKHNDMVDLETKLASLPAEVPKIIAFESVYSMCGSIAPIEKICDLADKYGAITFLDEVHAVGMYGPHGAGVAEHLDYDIYASQDTANPISTKDTIMDRIDIITGTLGKAYGCVGGYIAGSSKLVDTIRSLAPGFIFTTSLPPAIMAGANSAIEYQSRYSRDRTLQQLHTMAVKDAFKEIDIPVIPNPSHIVPLLVGDAELAKQASDMLLENHGIYVQAINYPTVPRGEERLRITPTPGHTKQYRNELVQAV |
Sequence similarities
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length613
- Mass (Da)66,465
- Last updated2014-11-26 v1
- Checksum685EA18459E45B6C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 82-102 | Pro residues | ||||
Sequence: MDAGKPAPRKPEVPLAGPHPQ |