A0A093T7P6 · A0A093T7P6_PHACA
- ProteinPhosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids581 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.
Catalytic activity
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphateThis reaction proceeds in the forward direction.
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphateThis reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphateThis reaction proceeds in the forward direction.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 268-271 | substrate | ||||
Sequence: NKAK | ||||||
Binding site | 293-294 | substrate | ||||
Sequence: NI | ||||||
Active site | 355 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 355-361 | substrate | ||||
Sequence: CSDGWDR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Molecular Function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Biological Process | phosphatidylinositol dephosphorylation |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Aequornithes > Suliformes > Phalacrocoracidae > Phalacrocorax
Accessions
- Primary accessionA0A093T7P6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Early endosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 143-518 | Myotubularin phosphatase | ||||
Sequence: GWKVYDPTWEYRRQGIPNESWRLTKINERYELCDTYPAILAVPVNIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGMSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSLLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCSSEQQRVKESLPKKTVSLWSYINSQLEDFTNPLYVSYNNHVLYPVASMRHLELWVGYY | ||||||
Domain | 324-371 | Tyrosine specific protein phosphatases | ||||
Sequence: THWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSLL | ||||||
Region | 554-581 | Disordered | ||||
Sequence: REITNRSTSSSERAGSPAQCVAPVQTVV |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length581
- Mass (Da)67,173
- Last updated2014-11-26 v1
- Checksum2BE03CDF34C69023
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V | ||||||
Non-terminal residue | 581 | |||||
Sequence: V |
Keywords
- Technical term