A0A093T7P6 · A0A093T7P6_PHACA

Function

function

Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.

Catalytic activity

  • 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.95 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
    This reaction proceeds in the forward direction.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site268-271substrate
Binding site293-294substrate
Active site355Phosphocysteine intermediate
Binding site355-361substrate

GO annotations

AspectTerm
Cellular Componentearly endosome membrane
Molecular Functionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Molecular Functionphosphatidylinositol-3-phosphate phosphatase activity
Biological Processphosphatidylinositol dephosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
  • EC number
  • Alternative names
    • Myotubularin-related protein 2
    • Phosphatidylinositol-3-phosphate phosphatase

Gene names

    • ORF names
      N336_04059

Organism names

  • Taxonomic identifier
  • Strain
    • BGI_N336
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Aequornithes > Suliformes > Phalacrocoracidae > Phalacrocorax

Accessions

  • Primary accession
    A0A093T7P6

Proteomes

Subcellular Location

Cytoplasm
Early endosome membrane
; Peripheral membrane protein

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain143-518Myotubularin phosphatase
Domain324-371Tyrosine specific protein phosphatases
Region554-581Disordered

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    581
  • Mass (Da)
    67,173
  • Last updated
    2014-11-26 v1
  • Checksum
    2BE03CDF34C69023
VLRETNKLAEMEEPPLLPGETIKDMAKDVTYICPFTGAIRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASSRGENSYGLEIVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKVYDPTWEYRRQGIPNESWRLTKINERYELCDTYPAILAVPVNIPDEELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGMSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLSLLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCSSEQQRVKESLPKKTVSLWSYINSQLEDFTNPLYVSYNNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPVHNRYKELLAKRAELQKKVEELQREITNRSTSSSERAGSPAQCVAPVQTVV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue581

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KL426991
EMBL· GenBank· DDBJ
KFW90579.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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