A0A093BM47 · A0A093BM47_CHAPE
- ProteinPhosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids609 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 186 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 186-190 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNLMH | ||||||
Binding site | 190 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 226 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 227 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 227 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 227 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 334 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 334 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 385 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cyclic-AMP phosphodiesterase activity | |
Molecular Function | 3',5'-cyclic-GMP phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Caprimulgimorphae > Apodiformes > Apodidae > Apodinae > Chaetura
Accessions
- Primary accessionA0A093BM47
Proteomes
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 109-486 | PDEase | ||||
Sequence: VGLSYPPAVIGVLKNVDKWSFDVFALNDASGDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLFKTGVVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQDDEEMNILSNLSKDDWREFRALVIEMVLATDMSCHFQQIKAMKNALQQPEGIDKPKALSLLLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIDEASRSGMSGFRRSSLNSISPSEVKRSSVKSTGSEGSASLNCSILTVDFKCFKATWTEVVQQNREKWKAQATKE | ||||||
Compositional bias | 483-530 | Basic and acidic residues | ||||
Sequence: ATKEEKAKKEAEENAHQGTDEKKTDEKDEKPSEDATAAKTENSKETNP | ||||||
Region | 483-609 | Disordered | ||||
Sequence: ATKEEKAKKEAEENAHQGTDEKKTDEKDEKPSEDATAAKTENSKETNPGENRSADSNKSNVNGTQQTGVNKHEASQGKNTSRTDKGTDSHHSAGEEKQHVQNGELKEDNKLEKKDHSSVGDESKKTD | ||||||
Compositional bias | 531-558 | Polar residues | ||||
Sequence: GENRSADSNKSNVNGTQQTGVNKHEASQ | ||||||
Compositional bias | 559-609 | Basic and acidic residues | ||||
Sequence: GKNTSRTDKGTDSHHSAGEEKQHVQNGELKEDNKLEKKDHSSVGDESKKTD |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Family and domain databases
Sequence
- Sequence statusFragment
- Length609
- Mass (Da)68,911
- Last updated2014-11-26 v1
- Checksum2C11274CBA79CF77
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: R | ||||||
Compositional bias | 483-530 | Basic and acidic residues | ||||
Sequence: ATKEEKAKKEAEENAHQGTDEKKTDEKDEKPSEDATAAKTENSKETNP | ||||||
Compositional bias | 531-558 | Polar residues | ||||
Sequence: GENRSADSNKSNVNGTQQTGVNKHEASQ | ||||||
Compositional bias | 559-609 | Basic and acidic residues | ||||
Sequence: GKNTSRTDKGTDSHHSAGEEKQHVQNGELKEDNKLEKKDHSSVGDESKKTD | ||||||
Non-terminal residue | 609 | |||||
Sequence: D |
Keywords
- Technical term