A0A091RSU0 · A0A091RSU0_NESNO

  • Protein
    7-dehydrocholesterol reductase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Function7-dehydrocholesterol reductase activity
Biological Processbrassinosteroid biosynthetic process
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Short names
    7-DHC
  • Alternative names
    • Sterol Delta(7)-reductase

Gene names

    • ORF names
      N333_00872

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BGI_N333
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Psittaciformes > Psittacidae > Nestor

Accessions

  • Primary accession
    A0A091RSU0

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical
Transmembrane59-79Helical
Transmembrane115-132Helical
Transmembrane144-164Helical
Transmembrane204-222Helical
Transmembrane229-249Helical
Transmembrane269-287Helical
Transmembrane299-318Helical
Transmembrane382-407Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    442
  • Mass (Da)
    51,783
  • Last updated
    2014-11-26 v1
  • MD5 Checksum
    7A1C2DA2E55BA504E53F1F0F032F13D6
EVDWFSLASVLFLLMFAPLIVYYFIMSCDQYQCSLMNPLIDLLTGNKHLSDIWNKTPMLTYRAAGIYTLWVTFQVALYMCLPDFCHKFLPGYVGGVQEGAVTPAGVVNKYEINGLQAWIITHMLWFANAYYFHYFSPTIIFDNWIPLMWCANILGYAVSTFAMIKGYFFPTNPKDCKFTGNFFYDYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQELYGQVTNSMILVNVLQGIYVLDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLGTANAIGILILGFIGYYIFRMTNHQKDLFRRTNSNCKIWGKKPEYIECSYMSVDGTKYYSKLMTSGFWGWARHFNYTGDLMGSLAYCLACGFEHILPYFYIVYMTILLTHRCIRDEHRCLSKYGKDWKRYTAAVPYRLLPGVF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue442

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KK932546
EMBL· GenBank· DDBJ
KFQ45710.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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