A0A091RSU0 · A0A091RSU0_NESNO
- Protein7-dehydrocholesterol reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids442 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.
Catalytic activity
- 7-dehydrodesmosterol + NADPH + H+ = desmosterol + NADP+This reaction proceeds in the forward direction.
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | 7-dehydrocholesterol reductase activity | |
Biological Process | brassinosteroid biosynthetic process | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-dehydrocholesterol reductase
- EC number
- Short names7-DHC
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Psittaciformes > Psittacidae > Nestor
Accessions
- Primary accessionA0A091RSU0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | |||
Transmembrane | 59-79 | Helical | |||
Transmembrane | 115-132 | Helical | |||
Transmembrane | 144-164 | Helical | |||
Transmembrane | 204-222 | Helical | |||
Transmembrane | 229-249 | Helical | |||
Transmembrane | 269-287 | Helical | |||
Transmembrane | 299-318 | Helical | |||
Transmembrane | 382-407 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length442
- Mass (Da)51,783
- Last updated2014-11-26 v1
- MD5 Checksum7A1C2DA2E55BA504E53F1F0F032F13D6
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 442 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KK932546 EMBL· GenBank· DDBJ | KFQ45710.1 EMBL· GenBank· DDBJ | Genomic DNA |