A0A091P697 · A0A091P697_LEPDC

Function

function

Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters.

Catalytic activity

  • (5Z)-tetradecenoyl-CoA + (R)-carnitine = O-(5Z)-tetradecenoyl-(R)-carnitine + CoA
  • (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  • (9Z)-tetradecenoyl-CoA + (R)-carnitine = O-(9Z)-tetradecenoyl-(R)-carnitine + CoA
  • 4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA
  • decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA
  • dodecanoyl-CoA + (R)-carnitine = O-dodecanoyl-R-carnitine + CoA
  • eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA
  • (R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.21 (UniProtKB | ENZYME | Rhea)
  • (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
  • octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA
  • tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site322Proton acceptor

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncarnitine O-palmitoyltransferase activity
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carnitine O-palmitoyltransferase 2, mitochondrial
  • EC number
  • Alternative names
    • Carnitine palmitoyltransferase II

Gene names

    • ORF names
      N330_09046

Organism names

  • Taxonomic identifier
  • Strain
    • BGI_N330
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Coraciimorphae > Coraciiformes > Leptosomidae > Leptosomus

Accessions

  • Primary accession
    A0A091P697

Proteomes

Subcellular Location

Mitochondrion inner membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-590Choline/carnitine acyltransferase

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    605
  • Mass (Da)
    68,563
  • Last updated
    2014-11-26 v1
  • Checksum
    DDFC677823063066
RLPVPKLEDTIRRYLNAQKPLLNDDQFRKTEELAHHFEKGIGRELHEQLVAQDNQNKHTSYITGPWFDMYLKAREPVVLNFNAFMSFNPDPKSEYNDQLIRATNMTVSAVRFMKTFRAGYLEPEVFHLNPEKSDTQIFKKIIRFVPPSLSWFGAYMVNAYPLDMSQYFRLFNSTRLPKLNRDELYTDETAKHLLVLRNGNFYVFDVIDRDGNMLKPSEIQAHLKYILSDNSPAPAFPLGYLSGENRDTWALLRNNLLDNGNEEALKKVDSAVFCLSLDDFPVKDFVHVSHTMLHGDGANRWYDKSFNLIITKDGTAGVNFEHSWGDGVAVLRFQNEVFKDSTKAPAISPQSQPASVDSSRAVRKLDFKLNDALKAGITKAKQKFDANVEALSLNLIQFHEGGKDLLKQKKVSPDAVAQLAFQMAFLRQYNQTVATYESCSTAAFRHGRTEAIRPASVHTKKCSEAFVRELSKHSTEELQKLIVECSKYHGRLTKEAAMGQGFDRHLFGLRYLALSKGIALPDLYQDQAYAQLNHNIISTSTLMSPAVQLGGFGPVVSDGLGVGYQVHDNWIGCNVSSYPTRNGTEFLQCVYKSLEDIFNVLKGKK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue605

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KK668361
EMBL· GenBank· DDBJ
KFQ02911.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp