A0A091KNX7 · A0A091KNX7_9AVES
- Protein11-beta-hydroxysteroid dehydrogenase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids218 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP+ = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP+This reaction proceeds in the forward direction.
- 3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H+ = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP+This reaction proceeds in the forward direction.
- 7-oxocholesterol + NADPH + H+ = 7beta-hydroxycholesterol + NADP+This reaction proceeds in the forward direction.
- 7-oxolithocholate + NADPH + H+ = ursodeoxycholate + NADP+This reaction proceeds in the forward direction.
- 7-oxopregnenolone + NADPH + H+ = 7beta-hydroxypregnenolone + NADP+This reaction proceeds in the forward direction.
- taurochenodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- tauroursodeoxycholate + NADP+ = 7-oxotaurolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- chenodeoxycholate + NADP+ = 7-oxolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- corticosterone + NADP+ = 11-dehydrocorticosterone + NADPH + H+This reaction proceeds in the forward and the backward directions.
- glycochenodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+This reaction proceeds in the backward direction.
- glycoursodeoxycholate + NADP+ = 7-oxoglycolithocholate + NADPH + H+This reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity | |
Molecular Function | steroid binding | |
Biological Process | steroid catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name11-beta-hydroxysteroid dehydrogenase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Otidimorphae > Otidiformes > Otididae > Chlamydotis
Accessions
- Primary accessionA0A091KNX7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type II membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MGLLLKIFTPLLGLALA | ||||||
Chain | PRO_5001875908 | 18-218 | 11-beta-hydroxysteroid dehydrogenase 1 | |||
Sequence: FYFYSAPENFNEEMLRGKRVIVTGASSGIGEQMAYHLARMEAHLLLTARTEAKLQKVVERCLELGAASARYVSGSMEDTTFPMVVVKEAEITWGGLDMLIINHIGFSYFNYFNGDVGHVRKLLETNFLSYVALTVSALPMLKESEGSIVVVSSMAGKTAGPFTAPYSATKFALDGFFSSLRQEFIIDKVNVSITLCILGYI |
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusFragment
- Length218
- Mass (Da)23,933
- Last updated2014-11-26 v1
- Checksum3E5EF4957870BA36
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 218 | |||||
Sequence: I |
Keywords
- Technical term