A0A091CKG8 · A0A091CKG8_FUKDA

Function

function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster.
[3Fe-4S] cluster (UniProtKB | Rhea| CHEBI:21137 )

Note: Binds 1 [3Fe-4S] cluster.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Function3 iron, 4 sulfur cluster binding
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATPase-coupled monoatomic cation transmembrane transporter activity
Molecular Functionelectron transfer activity
Molecular Functionmetal ion binding
Molecular FunctionP-type ion transporter activity
Molecular Functionsuccinate dehydrogenase (quinone) activity
Biological Processautophagosome-lysosome fusion
Biological Processintracellular calcium ion homeostasis
Biological Processregulation of autophagosome size
Biological Processregulation of mitochondrion organization
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
  • EC number
  • Recommended name
    Cation-transporting ATPase
  • EC number

Gene names

    • ORF names
      H920_19443

Organism names

Accessions

  • Primary accession
    A0A091CKG8

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Peripheral membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane614-636Helical
Transmembrane748-768Helical
Transmembrane780-807Helical
Transmembrane1258-1277Helical
Transmembrane1283-1300Helical
Transmembrane1321-1351Helical
Transmembrane1371-1388Helical
Transmembrane1400-1420Helical
Transmembrane1440-1460Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain40-1312Fe-2S ferredoxin-type
Domain176-2064Fe-4S ferredoxin-type
Region1122-1143Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,503
  • Mass (Da)
    164,810
  • Last updated
    2014-11-26 v1
  • Checksum
    A90C5435CED81FB1
MAAVAGFSLRRRFPATVLGGSCLQACRGAQTAADRAPRIKKFAIYRWDPDKTGDKPRMQTYEIDLNKCGPMVLDALIKIKNEMDATLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLGKVSKIYPLPHMYVIKDLVPDLNNFYAQYKSIEPYLKKKDESKEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTQTCPKHSCPVISERQSEAGDKRSSLKSEAELAWKLLCSRQPHPSGRCRVWAVTFCGWHLRVRPCTCELRQKCPASDSDQLWTSRSEDDLEGLQSRLRSRLHEQDSHWRDRHVHVMQSKPDSSPLAGSPPVSYGTLTIGTSVGPLSSSASSVRLSGYCGSPWRAIGYHAVVWVLAGIPLLLFRWKPLWGVRLRSRPCSLAHAETLVIETRDQEGSPWQLFTVQVQTEAVGEGSLELPLQTEDGHGELAVGAVPEAPWNDTAPLHREEAKRVARYYVFQGRRYVWMETQQAFLQVSLLGHGHTRDDIHRSQSGLSLPDQTVRRTIFGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIGLWLADHYYWYAVCIFLISAVSICLSIELVPGDCLVLPPEGGLMPCDAALVAGECVVNESCLTGESVPVVKTALPEGPGPYCPESHRRHTLFCGTLVLQARAYGGPHVLAVVTQTGFCTAKGALVSSILHPRPISFKFYKHSMKFVAALSVLALLGTMYSIFVLHRNQVPVNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRAQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLEGQAFLPLVPEPCFLPMGPLLRALATCHALSWLQDTPVGDPMDLKMVESTGWVLEEQPAADTALGTPILAAMRPPPWGPQTQGTEPPAPLGVLRRFPFSSTLQRMGVVVAWPGAAQPEAYVKGSPELVASLCRPDTVPADFSRTLQSYTAAGYRVVALACKPLPIGPSLEAARQLSRDTVEQDLSFLGLLVLRNLLKPQTTRVIQALRRTRIRTVMVTGDNLQTAVTVARGCGMVAPRERLVIVHATHPERGRPASLKFLPAECPTSVNGAKDLDPAESRTVEPEPPSSHLALSGSTFDVLMKHFPKLLPKVLVQATIFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIREGRCSLDTSLSMFKYMALYSLTQFVSVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTQPALALGRARPPGALLSVPVLSSLLLQVALVAGVQLGGYFLVVAQPWFVPLNKTVPAPDNLPNYENTAVFTLSSFQYLILAAAVSKGAPFRQPLYTNVPFLVALVLLGSVLVGLILVPGLLQGPLGLRDIADTCFKLLLLGLAACNFVGAFLLESVLDQCLPACLQRLRPKRASKKLFKQLEQELAERPWPPLPAAGAVR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KN125163
EMBL· GenBank· DDBJ
KFO19149.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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