A0A091CKG8 · A0A091CKG8_FUKDA
- ProteinMultifunctional fusion protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1503 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Catalytic activity
- (R)-malate + a quinone = a quinol + enol-oxaloacetateThis reaction proceeds in the forward direction.
- (S)-malate + a quinone = a quinol + enol-oxaloacetateThis reaction proceeds in the forward direction.
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [2Fe-2S] cluster.
Note: Binds 1 [3Fe-4S] cluster.
Note: Binds 1 [4Fe-4S] cluster.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | 3 iron, 4 sulfur cluster binding | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATPase-coupled monoatomic cation transmembrane transporter activity | |
Molecular Function | electron transfer activity | |
Molecular Function | metal ion binding | |
Molecular Function | P-type ion transporter activity | |
Molecular Function | succinate dehydrogenase (quinone) activity | |
Biological Process | autophagosome-lysosome fusion | |
Biological Process | intracellular calcium ion homeostasis | |
Biological Process | regulation of autophagosome size | |
Biological Process | regulation of mitochondrion organization | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended nameSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
- EC number
- Recommended nameCation-transporting ATPase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Hystricomorpha > Bathyergidae > Fukomys
Accessions
- Primary accessionA0A091CKG8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 614-636 | Helical | ||||
Sequence: YYWYAVCIFLISAVSICLSIELV | ||||||
Transmembrane | 748-768 | Helical | ||||
Sequence: SMKFVAALSVLALLGTMYSIF | ||||||
Transmembrane | 780-807 | Helical | ||||
Sequence: IVIRALDLVTVVVPPALPAAMTVCTLYA | ||||||
Transmembrane | 1258-1277 | Helical | ||||
Sequence: YMALYSLTQFVSVLILYTIN | ||||||
Transmembrane | 1283-1300 | Helical | ||||
Sequence: LQFLAIDLVITTTVAVLM | ||||||
Transmembrane | 1321-1351 | Helical | ||||
Sequence: VPVLSSLLLQVALVAGVQLGGYFLVVAQPWF | ||||||
Transmembrane | 1371-1388 | Helical | ||||
Sequence: AVFTLSSFQYLILAAAVS | ||||||
Transmembrane | 1400-1420 | Helical | ||||
Sequence: NVPFLVALVLLGSVLVGLILV | ||||||
Transmembrane | 1440-1460 | Helical | ||||
Sequence: LLLLGLAACNFVGAFLLESVL |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 40-131 | 2Fe-2S ferredoxin-type | ||||
Sequence: KKFAIYRWDPDKTGDKPRMQTYEIDLNKCGPMVLDALIKIKNEMDATLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLGKVSKIYPLP | ||||||
Domain | 176-206 | 4Fe-4S ferredoxin-type | ||||
Sequence: DREKLDGLYECILCACCSTSCPSYWWNGDKY | ||||||
Region | 1122-1143 | Disordered | ||||
Sequence: VNGAKDLDPAESRTVEPEPPSS |
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,503
- Mass (Da)164,810
- Last updated2014-11-26 v1
- ChecksumA90C5435CED81FB1
Keywords
- Technical term