A0A090CQ94 · A0A090CQ94_PODAN

Function

function

Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site13-18NADP+ (UniProtKB | ChEBI)
Binding site96NADPH (UniProtKB | ChEBI)
Binding site120NADPH (UniProtKB | ChEBI)
Binding site212L-homoserine (UniProtKB | ChEBI)
Active site227Proton donor

GO annotations

AspectTerm
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processhomoserine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homoserine dehydrogenase
  • EC number
  • Short names
    HDH

Organism names

Accessions

  • Primary accession
    A0A090CQ94

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-147Aspartate/homoserine dehydrogenase NAD-binding
Domain155-358Homoserine dehydrogenase catalytic

Sequence similarities

Belongs to the homoserine dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    38,578
  • Last updated
    2014-11-26 v1
  • Checksum
    2F2D162F05DA36DA
MAAAKQVNIAIIGAGGVGKCFLGQLETLAQRRPSPKLVLTYISTSKKAIYNSDYAAIAINDVSSKLASSSQAPLAPPKLIEYLKSSGSKTVLVDNTSSQDVADAYPLFLGNGISIVTPNKKAFSGSYELWQEIFSAAEQSGAKVYHESSVGAGLPVISTLNDLVNTGDEVTKIEGVFSGTMSFLFNSFAPTSGKGGQWSAEVRKAKELGYTEPDPRDDLNGLDVARKLTILARLAGLEVESPTSFPVQSLIPKELESVATGDEFLEKLPAFDSQMEETKAAAEKEGKVVRFVGSIDVASKQVKVGLEKFDLSHPIAALKGSDNIISFYTKRYGSNPLIIQGAGAGGEVTAMGVTSDLIKVLSQVA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO904939
EMBL· GenBank· DDBJ
CDP28404.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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