A0A090CQ94 · A0A090CQ94_PODAN
- ProteinHomoserine dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids365 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of threonine and methionine from aspartate.
Catalytic activity
- L-homoserine + NADP+ = L-aspartate 4-semialdehyde + NADPH + H+This reaction proceeds in the backward direction.
Cofactor
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 13-18 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 96 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 120 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 212 | L-homoserine (UniProtKB | ChEBI) | |||
Active site | 227 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | homoserine dehydrogenase activity | |
Molecular Function | NADP binding | |
Biological Process | homoserine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomoserine dehydrogenase
- EC number
- Short namesHDH
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Podosporaceae > Podospora > Podospora anserina
Accessions
- Primary accessionA0A090CQ94
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 13-147 | Aspartate/homoserine dehydrogenase NAD-binding | |||
Domain | 155-358 | Homoserine dehydrogenase catalytic | |||
Sequence similarities
Belongs to the homoserine dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)38,578
- Last updated2014-11-26 v1
- Checksum2F2D162F05DA36DA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FO904939 EMBL· GenBank· DDBJ | CDP28404.1 EMBL· GenBank· DDBJ | Genomic DNA |