A0A090C993 · A0A090C993_PODAN

Function

function

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site133(6S)-NADPHX (UniProtKB | ChEBI)
Binding site186-192(6S)-NADPHX (UniProtKB | ChEBI)
Binding site228-232ATP (UniProtKB | ChEBI)
Binding site247-256ATP (UniProtKB | ChEBI)
Binding site257(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP-dependent NAD(P)H-hydrate dehydratase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ATP-dependent NAD(P)HX dehydratase

Organism names

Accessions

  • Primary accession
    A0A090C993

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain8-332YjeF C-terminal
Region85-111Disordered

Sequence similarities

Belongs to the NnrD/CARKD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    343
  • Mass (Da)
    37,098
  • Last updated
    2014-11-26 v1
  • Checksum
    76A8EC85336B5D0C
MSSATKEILGRVRQLIPPMLERFHKGQMGRVAVIGGSEDYTGAPYFSAMASARLGCDLSHVICTPTAATVIKTYSPNLMVHPLMRSLPSSPAKPAGEDSDPSTASKHDTDPSEIASRIIPLLSRLHVLVIGPGLGRDPLMQKTVALVIQAAKKQNIPMVLDADALLLICNDPDLVRGYQEAVLTPNVVEFERLAKALNIEKEVAKEGKETDRVERLARELGGVMVLQKGGKDHLSNGTVTYSVDLEGGKKRSGGQGDTLTGSIATFLGWRKAYHEGLWDVKHKMKEEETAGLAVFGGSVITRECSRLAFAKRGRSLQASDLTDEVHTAFLNIFGEVDEDVSKL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO904936
EMBL· GenBank· DDBJ
CDP23190.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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