A0A089XKA8 · A0A089XKA8_9LACT
- ProteinPutative ribose-phosphate pyrophosphokinase
- Geneprs2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids321 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Catalytic activity
- ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H+
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 41-43 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DGE | ||||||
Binding site | 100-101 | ATP (UniProtKB | ChEBI) | ||||
Sequence: RQ | ||||||
Binding site | 134 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 223 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 227-231 | D-ribose 5-phosphate (UniProtKB | ChEBI) | ||||
Sequence: NTGVT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | kinase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | ribose phosphate diphosphokinase activity | |
Biological Process | 5-phosphoribose 1-diphosphate biosynthetic process | |
Biological Process | nucleotide biosynthetic process | |
Biological Process | ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative ribose-phosphate pyrophosphokinase
- EC number
- Short namesRPPK
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Lactococcus
Accessions
- Primary accessionA0A089XKA8
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-124 | Ribose-phosphate pyrophosphokinase N-terminal | ||||
Sequence: LKLFALNSNPGLAEKISQFTGVPLGKLSSKQFSDGEIMINMEESVRSQDIFIVQSTSCPVNDHLWELLIMIDACKRASARTINVVIPYFGYARQDRTATSREPITAKLVADMIVKAG |
Sequence similarities
Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length321
- Mass (Da)35,250
- Last updated2014-11-26 v1
- Checksum7870298BCBF3AC53
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BLYG01000001 EMBL· GenBank· DDBJ | GFO79767.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOWLV010000003 EMBL· GenBank· DDBJ | MDG4976186.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOWLP010000001 EMBL· GenBank· DDBJ | MDG4980422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOWLY010000002 EMBL· GenBank· DDBJ | MDG4983044.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOWLO010000003 EMBL· GenBank· DDBJ | MDG5048588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAUCAY010000001 EMBL· GenBank· DDBJ | MDM7508888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JARQDC010000010 EMBL· GenBank· DDBJ | MDT2881705.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JARQDF010000010 EMBL· GenBank· DDBJ | MDT2916922.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAWHVL010000018 EMBL· GenBank· DDBJ | MDV2632822.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WIPC01000030 EMBL· GenBank· DDBJ | MQQ80855.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NCXG01000003 EMBL· GenBank· DDBJ | PAK67671.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MTJS01000002 EMBL· GenBank· DDBJ | PFG88520.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RAGV01000015 EMBL· GenBank· DDBJ | RQE30906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SAXH01000009 EMBL· GenBank· DDBJ | RWR46711.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VJWV01000021 EMBL· GenBank· DDBJ | TRW71961.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP118738 EMBL· GenBank· DDBJ | WEA54826.1 EMBL· GenBank· DDBJ | Genomic DNA |