A0A089XKA8 · A0A089XKA8_9LACT

  • Protein
    Putative ribose-phosphate pyrophosphokinase
  • Gene
    prs2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
Part of a set of proteins in which some residues (ACT_SITE, NP_BIND, REGION and BINDING) are not conserved.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site41-43ATP (UniProtKB | ChEBI)
Binding site100-101ATP (UniProtKB | ChEBI)
Binding site134Mg2+ (UniProtKB | ChEBI)
Binding site223D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site227-231D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processnucleotide biosynthetic process
Biological Processribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs2
    • Synonyms
      prs
    • ORF names
      B8W94_03120
      , BW154_03230
      , D6120_09820
      , EO246_08000
      , FNJ53_12810
      , GFV15_07800
      , LL1119B1_18230
      , OGZ38_05485
      , OGZ39_01930
      , OGZ50_05515
      , OGZ51_02660
      , P7H88_09465
      , P7H93_10235
      , PWP91_11145
      , QUF15_01055
      , RZO31_08015

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 3
    • 54
    • 537
    • 581
    • 593
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Lactococcus

Accessions

  • Primary accession
    A0A089XKA8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-124Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    321
  • Mass (Da)
    35,250
  • Last updated
    2014-11-26 v1
  • Checksum
    7870298BCBF3AC53
MVYSDSHLKLFALNSNPGLAEKISQFTGVPLGKLSSKQFSDGEIMINMEESVRSQDIFIVQSTSCPVNDHLWELLIMIDACKRASARTINVVIPYFGYARQDRTATSREPITAKLVADMIVKAGADRLLTLDIHAVQVQGFFDIPVDNLFTVPLFADYYRKSGLFGDDVIVVAPKNSGIKRARSLAEYLESAIAIVDYEDDDKNRENGYVIGNVSGKKVILIDDILNTGVTFANAANVVREAGASEIYAVASHGLFTSGAADVLEKADIKEILVTDSVVTNHRKPLNVKYLSAAEYLASAILRIHEGRPVSPLFEHEKPQD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BLYG01000001
EMBL· GenBank· DDBJ
GFO79767.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOWLV010000003
EMBL· GenBank· DDBJ
MDG4976186.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOWLP010000001
EMBL· GenBank· DDBJ
MDG4980422.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOWLY010000002
EMBL· GenBank· DDBJ
MDG4983044.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOWLO010000003
EMBL· GenBank· DDBJ
MDG5048588.1
EMBL· GenBank· DDBJ
Genomic DNA
JAUCAY010000001
EMBL· GenBank· DDBJ
MDM7508888.1
EMBL· GenBank· DDBJ
Genomic DNA
JARQDC010000010
EMBL· GenBank· DDBJ
MDT2881705.1
EMBL· GenBank· DDBJ
Genomic DNA
JARQDF010000010
EMBL· GenBank· DDBJ
MDT2916922.1
EMBL· GenBank· DDBJ
Genomic DNA
JAWHVL010000018
EMBL· GenBank· DDBJ
MDV2632822.1
EMBL· GenBank· DDBJ
Genomic DNA
WIPC01000030
EMBL· GenBank· DDBJ
MQQ80855.1
EMBL· GenBank· DDBJ
Genomic DNA
NCXG01000003
EMBL· GenBank· DDBJ
PAK67671.1
EMBL· GenBank· DDBJ
Genomic DNA
MTJS01000002
EMBL· GenBank· DDBJ
PFG88520.1
EMBL· GenBank· DDBJ
Genomic DNA
RAGV01000015
EMBL· GenBank· DDBJ
RQE30906.1
EMBL· GenBank· DDBJ
Genomic DNA
SAXH01000009
EMBL· GenBank· DDBJ
RWR46711.1
EMBL· GenBank· DDBJ
Genomic DNA
VJWV01000021
EMBL· GenBank· DDBJ
TRW71961.1
EMBL· GenBank· DDBJ
Genomic DNA
CP118738
EMBL· GenBank· DDBJ
WEA54826.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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