A0A089XGV6 · A0A089XGV6_9LACT
- ProteinATP-dependent Clp protease proteolytic subunit
- GeneclpP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids199 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Catalytic activity
- Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 99 | ||||
Active site | 99 | Nucleophile | |||
Active site | 124 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | endopeptidase Clp complex | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | ATPase binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent Clp protease proteolytic subunit
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Lactococcus
Accessions
- Primary accessionA0A089XGV6
Proteomes
Subcellular Location
Interaction
Subunit
Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
Structure
Sequence
- Sequence statusComplete
- Length199
- Mass (Da)22,082
- Last updated2014-11-26 v1
- ChecksumE2DD1283588DA08F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAOWLV010000006 EMBL· GenBank· DDBJ | MDG4977127.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOWLP010000007 EMBL· GenBank· DDBJ | MDG4981889.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOWLY010000007 EMBL· GenBank· DDBJ | MDG4984155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAUCAG010000004 EMBL· GenBank· DDBJ | MDM7537074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAUCAE010000001 EMBL· GenBank· DDBJ | MDM7545621.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JARQDL010000008 EMBL· GenBank· DDBJ | MDT2946192.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAWHVL010000040 EMBL· GenBank· DDBJ | MDV2633805.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WIPC01000028 EMBL· GenBank· DDBJ | MQQ80818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WWDJ01000002 EMBL· GenBank· DDBJ | NEX54238.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NCWV01000002 EMBL· GenBank· DDBJ | PAK89997.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MTJS01000002 EMBL· GenBank· DDBJ | PFG89762.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RAGV01000003 EMBL· GenBank· DDBJ | RQE33759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SAXH01000007 EMBL· GenBank· DDBJ | RWR47162.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
OGTW02000014 EMBL· GenBank· DDBJ | SPS10720.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VJWV01000008 EMBL· GenBank· DDBJ | TRW73031.1 EMBL· GenBank· DDBJ | Genomic DNA |