A0A089XGV6 · A0A089XGV6_9LACT

  • Protein
    ATP-dependent Clp protease proteolytic subunit
  • Gene
    clpP
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.

Catalytic activity

  • Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
    EC:3.4.21.92 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

119920406080100120140160180
TypeIDPosition(s)Description
Active site99
Active site99Nucleophile
Active site124

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendopeptidase Clp complex
Molecular FunctionATP-dependent peptidase activity
Molecular FunctionATPase binding
Molecular Functionserine-type endopeptidase activity
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent Clp protease proteolytic subunit
  • EC number
  • Alternative names
    • Endopeptidase Clp

Gene names

    • Name
      clpP
    • ORF names
      AMHIJAGA_00650
      , B8W88_02275
      , BW154_09930
      , D6120_02980
      , EO246_07270
      , FNJ53_09445
      , GFV15_07615
      , GTP08_00550
      , OGZ39_09475
      , OGZ50_10315
      , OGZ51_08360
      , P7I04_09080
      , QUD52_01030
      , QUD55_06265
      , RZO31_13205

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 3
    • 54
    • 537
    • 581
    • OG2
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Lactococcus

Accessions

  • Primary accession
    A0A089XGV6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

Family & Domains

Sequence similarities

Belongs to the peptidase S14 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    199
  • Mass (Da)
    22,082
  • Last updated
    2014-11-26 v1
  • Checksum
    E2DD1283588DA08F
MGYLVPTVIEQSSRGERAYDIYSRLLKDRIIMLTGPVEDGMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMNFIKSDVQTIVMGMAASMGTIIASSGTKGKRFMLPNAEYLIHQPMGGTGQGTQQTDMAIVAEQLLKTRKRLEQILADNSNRSLEQIHKDAERDHWMDAKETLEYGFIDEIMENNSLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAOWLV010000006
EMBL· GenBank· DDBJ
MDG4977127.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOWLP010000007
EMBL· GenBank· DDBJ
MDG4981889.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOWLY010000007
EMBL· GenBank· DDBJ
MDG4984155.1
EMBL· GenBank· DDBJ
Genomic DNA
JAUCAG010000004
EMBL· GenBank· DDBJ
MDM7537074.1
EMBL· GenBank· DDBJ
Genomic DNA
JAUCAE010000001
EMBL· GenBank· DDBJ
MDM7545621.1
EMBL· GenBank· DDBJ
Genomic DNA
JARQDL010000008
EMBL· GenBank· DDBJ
MDT2946192.1
EMBL· GenBank· DDBJ
Genomic DNA
JAWHVL010000040
EMBL· GenBank· DDBJ
MDV2633805.1
EMBL· GenBank· DDBJ
Genomic DNA
WIPC01000028
EMBL· GenBank· DDBJ
MQQ80818.1
EMBL· GenBank· DDBJ
Genomic DNA
WWDJ01000002
EMBL· GenBank· DDBJ
NEX54238.1
EMBL· GenBank· DDBJ
Genomic DNA
NCWV01000002
EMBL· GenBank· DDBJ
PAK89997.1
EMBL· GenBank· DDBJ
Genomic DNA
MTJS01000002
EMBL· GenBank· DDBJ
PFG89762.1
EMBL· GenBank· DDBJ
Genomic DNA
RAGV01000003
EMBL· GenBank· DDBJ
RQE33759.1
EMBL· GenBank· DDBJ
Genomic DNA
SAXH01000007
EMBL· GenBank· DDBJ
RWR47162.1
EMBL· GenBank· DDBJ
Genomic DNA
OGTW02000014
EMBL· GenBank· DDBJ
SPS10720.1
EMBL· GenBank· DDBJ
Genomic DNA
VJWV01000008
EMBL· GenBank· DDBJ
TRW73031.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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