Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma.
Our replicated associations with HK1 and IL18R1 suggest that variants in inflammatory pathways such as the biologically-plausible NLRP3 inflammasome may contribute to nocturnal hypoxemia.
some SNPs of ST2-IL18R1-IL18RAP gene cluster might increase the risk of susceptibility of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in Chinese Han population.
The architecture of the IL-18 receptor second domain (D2) is unique among the other IL-1R family members which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode.
IL-18R downregulates IFN-alpha production by activation-induced splicing of IL-18Ralpha into 2 isoforms: the full-length receptor (IL-18Ralpha1) and a novel truncated variant (IL-18Ralpha2) a competitive molecular decoy inhibiting canonical IL-18Ralpha1/IL-18Rbeta signaling.
There was no association between the rs917997 in IL18R gene and rs187238 in IL18 gene polymorphisms and risk for non-Hodgkin's malignant lymphomas in Novosibirsk population.
results demonstrate clear functional consequences of the rs917997 risk polymorphism; this polymorphism leads to a loss-of-function through decreased IL-18RAP IL-18R1 and IL-1R1 protein expression which impairs autocrine IL-18 and IL-1 signaling
increased levels of soluble IL-18Ralpha complex in serum may also exert an antagonistic effect in vivo and play an important role in the inflammatory process in allergic asthma.
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