A0A088T0H9 · A0A088T0H9_TAPTE
- ProteinNatural resistance-associated macrophage protein 1
- GeneSlc11a1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids545 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Catalytic activity
- Fe2+(in) + H+(out) = Fe2+(out) + H+(in)
- H+(out) + Mn2+(in) = H+(in) + Mn2+(out)
- H+(out) + Zn2+(in) = H+(in) + Zn2+(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | phagocytic vesicle membrane | |
Cellular Component | plasma membrane | |
Molecular Function | cadmium ion transmembrane transporter activity | |
Molecular Function | iron ion transmembrane transporter activity | |
Molecular Function | manganese ion transmembrane transporter activity | |
Molecular Function | metal cation:proton antiporter activity | |
Biological Process | intracellular iron ion homeostasis | |
Biological Process | response to lipopolysaccharide |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNatural resistance-associated macrophage protein 1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Tapiridae > Tapirus
Accessions
- Primary accessionA0A088T0H9
Subcellular Location
UniProt Annotation
GO Annotation
Endosome membrane ; Multi-pass membrane protein
Late endosome membrane ; Multi-pass membrane protein
Lysosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 165-184 | Helical | ||||
Sequence: IPLWGGVLITIVDTFFFLFL | ||||||
Transmembrane | 196-214 | Helical | ||||
Sequence: FGCLITIMALTFGYEYVVA | ||||||
Transmembrane | 238-256 | Helical | ||||
Sequence: LLQAVGIVGAIIMPHNIYL | ||||||
Transmembrane | 277-303 | Helical | ||||
Sequence: ANMYFLIEAAIALSVSFFINLFVVAVF | ||||||
Transmembrane | 342-368 | Helical | ||||
Sequence: IYQGGVILGCLFGPAALYIWAVGLLAA | ||||||
Transmembrane | 395-414 | Helical | ||||
Sequence: FARVLLTRSCAILPTVLVAV | ||||||
Transmembrane | 434-452 | Helical | ||||
Sequence: LLLPFAVLPILTFTSMPAL | ||||||
Transmembrane | 464-486 | Helical | ||||
Sequence: IITSSIMALICAINLYFVVSYLP | ||||||
Transmembrane | 492-525 | Helical | ||||
Sequence: AYFGLVAVLAAVYLGLTAYLVWTCFIAHGATLLA |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length545
- Mass (Da)59,019
- Last updated2014-11-26 v1
- Checksum78403AF51D9A90AB