A0A088T0H9 · A0A088T0H9_TAPTE

Function

function

Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentlate endosome membrane
Cellular Componentlysosomal membrane
Cellular Componentphagocytic vesicle membrane
Cellular Componentplasma membrane
Molecular Functioncadmium ion transmembrane transporter activity
Molecular Functioniron ion transmembrane transporter activity
Molecular Functionmanganese ion transmembrane transporter activity
Molecular Functionmetal cation:proton antiporter activity
Biological Processintracellular iron ion homeostasis
Biological Processresponse to lipopolysaccharide

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Natural resistance-associated macrophage protein 1
  • Alternative names
    • Solute carrier family 11 member 1

Gene names

    • Name
      Slc11a1

Organism names

Accessions

  • Primary accession
    A0A088T0H9

Subcellular Location

Endosome membrane
; Multi-pass membrane protein
Late endosome membrane
; Multi-pass membrane protein
Lysosome membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane165-184Helical
Transmembrane196-214Helical
Transmembrane238-256Helical
Transmembrane277-303Helical
Transmembrane342-368Helical
Transmembrane395-414Helical
Transmembrane434-452Helical
Transmembrane464-486Helical
Transmembrane492-525Helical

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-38Disordered

Sequence similarities

Belongs to the NRAMP family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    545
  • Mass (Da)
    59,019
  • Last updated
    2014-11-26 v1
  • Checksum
    78403AF51D9A90AB
MAGDSGPQRLSRPSYGSISSPPTPGPTQGPPGGTYLSEKIPIPDTESGAFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTLLWLTIELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGCLITIMALTFGYEYVVARPDQGALLQGLFLPSCPGCGQPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRNSRADVREANMYFLIEAAIALSVSFFINLFVVAVFGQAFYQQTNQAAFNVCVNSSLHDYAKIFPENNLTVAVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLVAVFRDVRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPALMQEFANGLLSKIITSSIMALICAINLYFVVSYLPSLPHPAYFGLVAVLAAVYLGLTAYLVWTCFIAHGATLLAHSSHRQFLYGLPEEKPEPSG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KM508102
EMBL· GenBank· DDBJ
AIO10927.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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