A0A088BU32 · A0A088BU32_9NEOB

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1
    • Synonyms
      COX1

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A088BU32

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane16-36Helical
Transmembrane56-82Helical
Transmembrane103-125Helical
Transmembrane145-170Helical
Transmembrane182-209Helical
Transmembrane242-260Helical
Transmembrane267-290Helical
Transmembrane302-325Helical
Transmembrane337-358Helical
Transmembrane378-399Helical
Transmembrane411-429Helical
Transmembrane449-472Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-515Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    516
  • Mass (Da)
    57,338
  • Last updated
    2014-11-26 v1
  • Checksum
    B84C2E81D5680DEC
MFTRWFFSTNHKDIGTLYLIFGAWAGMIGTALSLLIRAELSQPGTLLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFFLLLASSTVEAGAGTGWTVYPPLAGNLAHAGPSVDLAIFSLHLAGVSSILGAINFITTILNMKPSSVTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTSFFDPAGGGDPVLYQHLFWFFGHPEVYILILPGFGIISHVVAYYSNKKEPFGYMGMVWAMLSIGLLGFIVWAHHMFTTDLNVDTRAYFTSATMIIAIPTGVKVFSWLATMHGGIIKWEAPMLWALGFIFLFTVGGLTGIILANSSIDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFTGFTLHELWTKIHFVVMFVGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTISSIGSLISLVAVVMMMFIIWEAFAAKRLFPGAKLTSTNIEWVLGFPPHYHTFEESTFSVKLMRE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF771343
EMBL· GenBank· DDBJ
AHG32650.1
EMBL· GenBank· DDBJ
Genomic DNA
KU641020
EMBL· GenBank· DDBJ
ANC62869.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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