WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation whereas the N-terminal portion is required for its regulation and localization in the cells
BLOC1S2 protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. Over-expression of BLOC1S2 in the presence or absence of HIPPI does not induce apoptosis.
Biogenesis of lysosome-related organelles complex-1 (BLOC-1) subunit 2 (BLOS2).BLOC-1 is required for the biogenesis of melanosomes and platelet dense granules.
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