A0A087WXP2 · A0A087WXP2_HUMAN

  • Protein
    Nuclear factor 1
  • Gene
    NFIX
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Biological ProcessDNA replication
Biological Processpositive regulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear factor 1

Gene names

    • Name
      NFIX

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A087WXP2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Variants

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The viewer provides 330 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)243PRIDEPhosphoserine
Modified residue (large scale data)249PRIDEPhosphoserine
Modified residue (large scale data)264PRIDEPhosphoserine
Modified residue (large scale data)266PRIDEPhosphothreonine
Modified residue (large scale data)267PRIDEPhosphoserine
Modified residue (large scale data)270PRIDEPhosphoserine
Modified residue (large scale data)279PRIDEPhosphoserine
Modified residue (large scale data)283PRIDEPhosphoserine
Modified residue (large scale data)287PRIDEPhosphoserine
Modified residue (large scale data)300PRIDEPhosphoserine
Modified residue (large scale data)321PRIDEPhosphoserine
Modified residue (large scale data)335PRIDEPhosphoserine
Modified residue (large scale data)336PRIDEPhosphoserine
Modified residue (large scale data)340PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Binds DNA as a homodimer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-193CTF/NF-I
Region263-319Disordered
Compositional bias300-314Polar residues

Sequence similarities

Belongs to the CTF/NF-I family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    393
  • Mass (Da)
    43,722
  • Last updated
    2022-05-25 v2
  • Checksum
    36FF4D21852B7D5B
MLPACRLQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPAFATTGASSANRFVSIGPRDGNFLNIPQQSQSWFL

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q14938NFIX_HUMANNFIX502
K7EJB0K7EJB0_HUMANNFIX183
C9JWJ8C9JWJ8_HUMANNFIX460
B4DHW2B4DHW2_HUMANNFIX510
A0A8J8YL86A0A8J8YL86_HUMANNFIX403
K7EKH0K7EKH0_HUMANNFIX128
K7EN08K7EN08_HUMANNFIX455
K7EMQ5K7EMQ5_HUMANNFIX101
K7EPU2K7EPU2_HUMANNFIX59
K7ESG9K7ESG9_HUMANNFIX125
A0A8I5KYE6A0A8I5KYE6_HUMANNFIX293

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias300-314Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC007787
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC022152
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC138474
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456509
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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