A0A087WWD5 · A0A087WWD5_HUMAN
- ProteinTafazzin family protein
- GeneTAFAZZIN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.
Catalytic activity
- 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipinThis reaction proceeds in the forward and the backward directions.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineThis reaction proceeds in the forward and the backward directions.
- 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphateThis reaction proceeds in the forward and the backward directions.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)This reaction proceeds in the forward and the backward directions.
- 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineThis reaction proceeds in the forward and the backward directions.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrial outer membrane | |
Molecular Function | acyltransferase activity | |
Biological Process | phospholipid metabolic process |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTafazzin family protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A087WWD5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Mitochondrion outer membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 15-34 | Helical | ||||
Sequence: LTWTLASSVVMGLVGTYSCF |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 65 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
Expression
Gene expression databases
Interaction
Subunit
Associates with multiple protein complexes.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-86 | Phospholipid/glycerol acyltransferase | ||||
Sequence: LTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRH |
Sequence similarities
Belongs to the taffazin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length95
- Mass (Da)11,150
- Last updated2014-10-29 v1
- ChecksumB9195367A4D576B5
Computationally mapped potential isoform sequences
There are 13 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q16635 | TAZ_HUMAN | TAFAZZIN | 262 | ||
C9J699 | C9J699_HUMAN | TAZ | 184 | ||
A0A499FJ53 | A0A499FJ53_HUMAN | TAZ | 280 | ||
F6Y2X3 | F6Y2X3_HUMAN | TAFAZZIN | 262 | ||
H7C2I9 | H7C2I9_HUMAN | TAFAZZIN | 34 | ||
A6XNE1 | A6XNE1_HUMAN | TAFAZZIN | 296 | ||
A0A494C004 | A0A494C004_HUMAN | TAZ | 311 | ||
A0A494C0V5 | A0A494C0V5_HUMAN | TAZ | 186 | ||
A0A494C1C6 | A0A494C1C6_HUMAN | TAFAZZIN | 31 | ||
A0A494C1B0 | A0A494C1B0_HUMAN | TAFAZZIN | 31 | ||
A0A494C141 | A0A494C141_HUMAN | TAZ | 265 | ||
A0A494C0D2 | A0A494C0D2_HUMAN | TAZ | 163 | ||
A0A494C0C5 | A0A494C0C5_HUMAN | TAZ | 223 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC244090 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC245140 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KU178351 EMBL· GenBank· DDBJ | ALQ33809.1 EMBL· GenBank· DDBJ | mRNA |