A0A087WWD5 · A0A087WWD5_HUMAN

  • Protein
    Tafazzin family protein
  • Gene
    TAFAZZIN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Acyltransferase which is required to remodel newly synthesized phospholipid cardiolipin, a key component of the mitochondrial inner membrane. Required for the initiation of mitophagy. Required to ensure progression of spermatocytes through meiosis.

Catalytic activity

  • 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + a cardiolipin
    This reaction proceeds in the forward
    and the backward
    directions.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward
    and the backward
    directions.
  • 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1-acyl-sn-glycero-3-phosphate = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate
    This reaction proceeds in the forward
    and the backward
    directions.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
    This reaction proceeds in the forward
    and the backward
    directions.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward
    and the backward
    directions.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial outer membrane
Molecular Functionacyltransferase activity
Biological Processphospholipid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tafazzin family protein

Gene names

    • Name
      TAFAZZIN
    • Synonyms
      TAZ

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A087WWD5

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion inner membrane
; Peripheral membrane protein
Mitochondrion outer membrane
; Peripheral membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-34Helical

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 65 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

Expression

Gene expression databases

Interaction

Subunit

Associates with multiple protein complexes.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain42-86Phospholipid/glycerol acyltransferase

Sequence similarities

Belongs to the taffazin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    95
  • Mass (Da)
    11,150
  • Last updated
    2014-10-29 v1
  • Checksum
    B9195367A4D576B5
MPLHVKWPFPAVPPLTWTLASSVVMGLVGTYSCFWTKYMNHLTVHNREVLYELIEKRGPATPLITVSNHQSCMDDPHLWGILKLRHIWNLKLMRW

Computationally mapped potential isoform sequences

There are 13 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q16635TAZ_HUMANTAFAZZIN262
C9J699C9J699_HUMANTAZ184
A0A499FJ53A0A499FJ53_HUMANTAZ280
F6Y2X3F6Y2X3_HUMANTAFAZZIN262
H7C2I9H7C2I9_HUMANTAFAZZIN34
A6XNE1A6XNE1_HUMANTAFAZZIN296
A0A494C004A0A494C004_HUMANTAZ311
A0A494C0V5A0A494C0V5_HUMANTAZ186
A0A494C1C6A0A494C1C6_HUMANTAFAZZIN31
A0A494C1B0A0A494C1B0_HUMANTAFAZZIN31
A0A494C141A0A494C141_HUMANTAZ265
A0A494C0D2A0A494C0D2_HUMANTAZ163
A0A494C0C5A0A494C0C5_HUMANTAZ223

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC244090
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC245140
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KU178351
EMBL· GenBank· DDBJ
ALQ33809.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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