Tthe blockage of Cav1.2 increased the TC while reduced the iCa(2+) signal. Similar results were observed after the blockage of TRPs or BKCa. Therefore caffeine promoted Ca(2+)-influx via TRPs and Cav1.2 and hyperpolarization through the activation of BKCa inducing negative feedback of TC.
Caveolae play a critical role in protein targeting and preserving the close structural relationship between CaV3.2 and RyR needed to drive BKCa-mediated feedback control in resistance arteries.
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