Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis.Alam S.S., Kumar S., Beauchamp M.C., Bareke E., Boucher A., Nzirorera N., Dong Y., Padilla R., Zhang S.J.[...], Jerome-Majewska L.A.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCDis Model Mech 15:dmm049544-dmm049544 (2022)Mapped to82
Mdm4 controls ureteric bud branching via regulation of p53 activity.Hilliard S.A., Li Y., Dixon A., El-Dahr S.S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCMech Dev 163:103616-103616 (2020)Mapped to99+
Role of smooth muscle cell p53 in pulmonary arterial hypertension.Wakasugi T., Shimizu I., Yoshida Y., Hayashi Y., Ikegami R., Suda M., Katsuumi G., Nakao M., Hoyano M.[...], Minamino T.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCPLoS One 14:e0212889-e0212889 (2019)Mapped to21
Inhibition of Mdmx (Mdm4) <i>in vivo</i> induces anti-obesity effects.Kon N., Wang D., Li T., Jiang L., Qiang L., Gu W.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCOncotarget 9:7282-7297 (2018)Mapped to21
The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.Xiong S., Pant V., Zhang Y., Aryal N.K., You M.J., Kusewitt D., Lozano G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCJ Pathol 241:501-510 (2017)Mapped to35
Loss of oocytes due to conditional ablation of Murine double minute 2 (Mdm2) gene is p53-dependent and results in female sterility.Livera G., Uzbekov R., Jarrier P., Fouchecourt S., Duquenne C., Parent A.S., Marine J.C., Monget P.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCFEBS Lett 590:2566-2574 (2016)Mapped to33
Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity.Bardot B., Bouarich-Bourimi R., Leemput J., Lejour V., Hamon A., Plancke L., Jochemsen A.G., Simeonova I., Fang M., Toledo F.View abstractCategoriesFunction, Sequences, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCOncogene 34:2943-2948 (2015)Mapped to21
Mutant mice lacking the p53 C-terminal domain model telomere syndromes.Simeonova I., Jaber S., Draskovic I., Bardot B., Fang M., Bouarich-Bourimi R., Lejour V., Charbonnier L., Soudais C.[...], Toledo F.View abstractCategoryPhenotypes & VariantsSourceMGI: 107934PubMedEurope PMCCell Rep 3:2046-2058 (2013)Mapped to26
Mdm4 loss in mice expressing a p53 hypomorph alters tumor spectrum without improving survival.Fang M., Simeonova I., Bardot B., Lejour V., Jaber S., Bouarich-Bourimi R., Morin A., Toledo F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCOncogene 33:1336-1339 (2014)Mapped to31
Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.Zhang Q., He X., Chen L., Zhang C., Gao X., Yang Z., Liu G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCJ Pathol 228:416-428 (2012)Mapped to54
Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.Terzian T., Dumble M., Arbab F., Thaller C., Donehower L.A., Lozano G., Justice M.J., Roop D.R., Box N.F.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCJ Pathol 224:540-552 (2011)Mapped to28
Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo.De Clercq S., Gembarska A., Denecker G., Maetens M., Naessens M., Haigh K., Haigh J.J., Marine J.C.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCMol Cell Biol 30:5394-5405 (2010)Mapped to34
Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases.Wang Y.V., Leblanc M., Wade M., Jochemsen A.G., Wahl G.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCCancer Cell 16:33-43 (2009)Mapped to27
Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities.Valentin-Vega Y.A., Box N., Terzian T., Lozano G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCDifferentiation 77:442-449 (2009)Mapped to7
EUCOMM--the European conditional mouse mutagenesis program.Friedel R.H., Seisenberger C., Kaloff C., Wurst W.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCBrief Funct Genomic Proteomic 6:180-185 (2007)Mapped to99+
Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.Xiong S., Van Pelt C.S., Elizondo-Fraire A.C., Fernandez-Garcia B., Lozano G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCCirculation 115:2925-2930 (2007)Mapped to28
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.Xiong S., Van Pelt C.S., Elizondo-Fraire A.C., Liu G., Lozano G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCProc Natl Acad Sci U S A 103:3226-3231 (2006)Mapped to36
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.Grier J.D., Xiong S., Elizondo-Fraire A.C., Parant J.M., Lozano G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCMol Cell Biol 26:192-198 (2006)Mapped to32
Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.Iwakuma T., Parant J.M., Fasulo M., Zwart E., Jacks T., de Vries A., Lozano G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCOncogene 23:7644-7650 (2004)Mapped to33
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.Chavez-Reyes A., Parant J.M., Amelse L.L., de Oca Luna R.M., Korsmeyer S.J., Lozano G.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 107934PubMedEurope PMCCancer Res 63:8664-8669 (2003)Mapped to45
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.Zambrowicz B.P., Abuin A., Ramirez-Solis R., Richter L.J., Piggott J., BeltrandelRio H., Buxton E.C., Edwards J., Finch R.A.[...], Sands A.T.View abstractCategoryPhenotypes & VariantsSourceMGI: 107934PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 100:14109-14114 (2003)Cited in1Mapped to99+