A0A087WP33 · A0A087WP33_MOUSE
- ProteinAutophagy-related protein 9
- GeneAtg9a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids847 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | autophagosome membrane | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | late endosome membrane | |
Cellular Component | mitochondrion | |
Cellular Component | phagophore assembly site membrane | |
Cellular Component | recycling endosome membrane | |
Cellular Component | trans-Golgi network | |
Molecular Function | phospholipid scramblase activity | |
Biological Process | autophagosome assembly |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAutophagy-related protein 9
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A087WP33
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein
Late endosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Preautophagosomal structure membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 63-85 | Helical | ||||
Sequence: LMQFLFVVAFTTFLVSCVDYDIL | ||||||
Transmembrane | 283-307 | Helical | ||||
Sequence: ILWIGIANFLLCPLILIWQILYAFF | ||||||
Transmembrane | 373-390 | Helical | ||||
Sequence: GAFFAGSILAVLIALTIY | ||||||
Transmembrane | 397-418 | Helical | ||||
Sequence: VEHVLTTVTLLGVTVTVCRSFI |
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 650-676 | Disordered | ||||
Sequence: PLQPGAAPQGRVPSTMTGSGVDARTAS | ||||||
Compositional bias | 659-676 | Polar residues | ||||
Sequence: GRVPSTMTGSGVDARTAS | ||||||
Region | 710-847 | Disordered | ||||
Sequence: HKQQTQAEPERHVWHRRESDESGESAPEEGGEGARAPQPIPRSASYPCATPRPGAPETTALHGGFQRRYGGITDPGTVPRGPSHFSRLPLGGWAEDGQPASRHPEPVPEEGSEDELPPQVHKVKAVRPRTTARSGDFQ | ||||||
Compositional bias | 713-733 | Basic and acidic residues | ||||
Sequence: QTQAEPERHVWHRRESDESGE | ||||||
Compositional bias | 811-831 | Basic and acidic residues | ||||
Sequence: RHPEPVPEEGSEDELPPQVHK |
Sequence similarities
Belongs to the ATG9 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length847
- Mass (Da)95,222
- Last updated2014-10-29 v1
- ChecksumBF065225E5A63227
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q68FE2 | ATG9A_MOUSE | Atg9a | 839 | ||
A0A087WQ26 | A0A087WQ26_MOUSE | Atg9a | 176 | ||
A0A087WPL8 | A0A087WPL8_MOUSE | Atg9a | 278 | ||
A0A087WRG3 | A0A087WRG3_MOUSE | Atg9a | 47 |
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: X | ||||||
Compositional bias | 659-676 | Polar residues | ||||
Sequence: GRVPSTMTGSGVDARTAS | ||||||
Compositional bias | 713-733 | Basic and acidic residues | ||||
Sequence: QTQAEPERHVWHRRESDESGE | ||||||
Compositional bias | 811-831 | Basic and acidic residues | ||||
Sequence: RHPEPVPEEGSEDELPPQVHK |
Keywords
- Technical term