A0A087RZP3 · A0A087RZP3_9ARCH
- ProteinMevalonate kinase
- Genemvk
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids313 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
Catalytic activity
- (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H+
Cofactor
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 147 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | mevalonate kinase activity | |
Biological Process | isopentenyl diphosphate biosynthetic process, mevalonate pathway | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMevalonate kinase
- EC number
- Short namesMK ; MVK
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Nitrososphaerota > Marine Group I
Accessions
- Primary accessionA0A087RZP3
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 89-155 | GHMP kinase N-terminal | ||||
Sequence: KIEVESEIPLGVGLGSSSACCIAGAAAISKLFKNISKDEILKLAIEAEKTIFQNTSGADCTVCTFGG | ||||||
Domain | 220-297 | GHMP kinase C-terminal | ||||
Sequence: LELLKEDNVKDLGQKAIQNQEYLEKIGISNDKLRDMIKIGQKASFGAKITGAGGGGCIFALTDESNLENTIKEFKENN |
Sequence similarities
Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length313
- Mass (Da)34,430
- Last updated2014-10-29 v1
- ChecksumB1D5EAEE47425686
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JOSZ01000011 EMBL· GenBank· DDBJ | KFM18947.1 EMBL· GenBank· DDBJ | Genomic DNA |