A0A087RZP3 · A0A087RZP3_9ARCH

Function

function

Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site147Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionmevalonate kinase activity
Biological Processisopentenyl diphosphate biosynthetic process, mevalonate pathway
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mevalonate kinase
  • EC number
  • Short names
    MK
    ; MVK

Gene names

    • Name
      mvk
    • ORF names
      AAA799P11_00893

Organism names

Accessions

  • Primary accession
    A0A087RZP3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain89-155GHMP kinase N-terminal
Domain220-297GHMP kinase C-terminal

Sequence similarities

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    313
  • Mass (Da)
    34,430
  • Last updated
    2014-10-29 v1
  • Checksum
    B1D5EAEE47425686
MKSKASAPGKVILFGEHFVVYGVKAILCAINKRIIVTAEEISERKISIKSNIGKLELEPNKPISEINSPLKPFYYLADKIIQDRDSGIKIEVESEIPLGVGLGSSSACCIAGAAAISKLFKNISKDEILKLAIEAEKTIFQNTSGADCTVCTFGGLMEYDKKNGFSKIESEPNFHLVIANSNVEHSTESVVAGVREFKENNEKEFSKLCEDESYLIENVLELLKEDNVKDLGQKAIQNQEYLEKIGISNDKLRDMIKIGQKASFGAKITGAGGGGCIFALTDESNLENTIKEFKENNYECFSVKIDFKGLDTF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JOSZ01000011
EMBL· GenBank· DDBJ
KFM18947.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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