A0A087RXQ4 · A0A087RXQ4_9ARCH

Function

function

Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site86Nucleophile
Active site194
Active site196

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionglutaminase activity
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase subunit PurQ
  • EC number
  • Short names
    FGAM synthase
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase subunit I
      (FGAR amidotransferase I
      ; FGAR-AT I
      )
    • Glutaminase PurQ
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)
    • Phosphoribosylformylglycinamidine synthase subunit I

Gene names

    • Name
      purQ
    • ORF names
      AAA799P11_01180

Organism names

Accessions

  • Primary accession
    A0A087RXQ4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.

Family & Domains

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    25,052
  • Last updated
    2014-10-29 v1
  • Checksum
    76BE9CAD902E395C
MKVGVVVFPGSNCDRDMYHVLTDVFNLDAQYYWHEKSLPKNIDAIVLPGGFSYGDRLRAGVIAAHSPIIKDVQKMAKKGVPVLGVCNGFQILVEAGLLPGVLLKNESLNFMCEWTNLVVENNTTPFTNQFKLHQKIPIPIANGEGRYYVDDDTLKQLTKKNQIVFRYDKVVNGSSNRIAGVCNEDGNVVGMMPHPERAVESEINPIDNKPSSLIFESLLSKMGVSN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JOSZ01000020
EMBL· GenBank· DDBJ
KFM18258.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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