A0A086P708 · A0A086P708_SPHHM

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site23-28substrate
Binding site55Mg2+ (UniProtKB | ChEBI)
Active site84Proton acceptor
Binding site84Mg2+ (UniProtKB | ChEBI)
Binding site85substrate
Binding site168-171substrate
Binding site191substrate
Binding site196-197substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      BV98_003003

Organism names

Accessions

  • Primary accession
    A0A086P708

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    209
  • Mass (Da)
    22,133
  • Last updated
    2014-10-29 v1
  • Checksum
    2EEC30F4298B1E4F
MSDDFGQEQAIRKLAPGKLVIASHNPGKVREIGELLAPYGIETVSAAELDLPEPEETGTTFIANAELKAMQAADLSGLPALADDSGLCVEALNGDPGIFSARWAGETKDFGIAMKLVWDAIEAKGPNAGHGAHFICALALAWPDGHVEAFEGRVDGTIAWPPRGEKGFGYDPIFQPLGHAITFGEMEPAKKHAMSHRADAFAQLVASVF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JFZA02000034
EMBL· GenBank· DDBJ
KFG89176.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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