A0A086KTD6 · A0A086KTD6_TOXGO

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, active site.

163950100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site138FAD (UniProtKB | ChEBI)
Binding site223FAD (UniProtKB | ChEBI)
Binding site305-312NAD+ (UniProtKB | ChEBI)
Binding site460FAD (UniProtKB | ChEBI)
Active site601Proton acceptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionglutathione-disulfide reductase (NADPH) activity
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processglutathione metabolic process

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • NADPH-glutathione reductase
      (EC:1.8.1.7
      )

Gene names

    • ORF names
      TGDOM2_219130

Organism names

  • Taxonomic identifier
  • Strain
    • GAB2-2007-GAL-DOM2
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma

Accessions

  • Primary accession
    A0A086KTD6

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_500180947623-639
Disulfide bond129↔134Redox-active

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain92-475FAD/NAD(P)-binding
Domain496-610Pyridine nucleotide-disulphide oxidoreductase dimerisation
Region616-639Disordered
Compositional bias619-639Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    639
  • Mass (Da)
    68,647
  • Last updated
    2014-10-29 v1
  • Checksum
    5F2796387F9499E0
MRFLAIVYVAVLFVIASSSVGSALNGGASHESLAYRRADESAANSLGEHFHAARSSCQYQQNATAFPSGATSIARTSERESAGEQEEAPAHFDLVVIGGGSGGVACARRAASYGASVAIVEKANIGGTCVNLGCMPKKVMWLASHLGASFDAMPYYGFAVPNDEENTRNSASKAESKKFFAGGRLAFSWERLRESRDAYVSRLRDTFARLLKEANVTVYRGVGRLDASFDRTGKSGNSSAQRCRPRHAVLIQTLEGKVQRVTANHVLIATGTRRQVLDIPGAEFAISSDGFFQIQHLPRRVALIGAGYVSAELGGILRHLGVDVSIFMRNQRQLKRFDKEAVESLEATQRASGIQLYKGVNAVEISISKADGTKLSASYTFHDQTETSYHLEDSLLTVHLDNGDAHHGFDHVIMAVNPAPAIEDLGLEEAGVDIDVNNGGFIKVDAFQNTSIPGIYAVGDVVGKAMLAPVAVAAGRLLADRLFGGRSEARLDLSVVPTVVFSHPALGAVGMTEEDAKSLYGEENINVYTSTFIDSFYAAWSMPPSAKPKSFVKMVCLKTANDKVLGLHLVGRNVDEMLQGFAVAIKLGATKADFNSTLAIHPTAAEEVVTLPHPKPVTRRATTMEEKNLDKESPLQRPV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias619-639Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AHZU02000175
EMBL· GenBank· DDBJ
KFG47654.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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