A0A086JEJ7 · A0A086JEJ7_TOXGO
- ProteinPutative rRNA methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids981 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.
Catalytic activity
- a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 62 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 64 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 82 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 98 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 123 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Active site | 163 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Cellular Component | preribosome, large subunit precursor | |
Molecular Function | rRNA (guanine) methyltransferase activity | |
Molecular Function | rRNA (uridine-2'-O-)-methyltransferase activity | |
Biological Process | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | |
Biological Process | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative rRNA methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma
Accessions
- Primary accessionA0A086JEJ7
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 29-206 | Ribosomal RNA methyltransferase FtsJ | |||
Region | 240-275 | Disordered | |||
Compositional bias | 259-274 | Acidic residues | |||
Domain | 309-452 | DUF3381 | |||
Region | 398-421 | Disordered | |||
Region | 500-544 | Disordered | |||
Compositional bias | 502-517 | Basic and acidic residues | |||
Compositional bias | 525-544 | Acidic residues | |||
Region | 556-581 | Disordered | |||
Region | 594-641 | Disordered | |||
Compositional bias | 608-627 | Acidic residues | |||
Region | 653-783 | Disordered | |||
Compositional bias | 700-767 | Basic and acidic residues | |||
Domain | 761-965 | Ribosomal RNA methyltransferase SPB1-like C-terminal | |||
Region | 926-981 | Disordered | |||
Compositional bias | 958-981 | Basic residues | |||
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length981
- Mass (Da)109,418
- Last updated2014-10-29 v1
- ChecksumC29FF2C023C36C38
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 259-274 | Acidic residues | |||
Compositional bias | 502-517 | Basic and acidic residues | |||
Compositional bias | 525-544 | Acidic residues | |||
Compositional bias | 608-627 | Acidic residues | |||
Compositional bias | 700-767 | Basic and acidic residues | |||
Compositional bias | 958-981 | Basic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AEYI02002043 EMBL· GenBank· DDBJ | KFG30565.1 EMBL· GenBank· DDBJ | Genomic DNA |