A0A085NLD8 · A0A085NLD8_9BILA

Function

function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

112181002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Active site307
Binding site308Ca2+ (UniProtKB | ChEBI)
Binding site337Ca2+ (UniProtKB | ChEBI)
Binding site339Ca2+ (UniProtKB | ChEBI)
Active site356
Binding site390Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncalcium ion binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processlipid catabolic process
Biological Processphosphatidylinositol-mediated signaling
Biological Processrelease of sequestered calcium ion into cytosol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • ORF names
      M514_09244

Organism names

  • Taxonomic identifier
  • Strain
    • DCEP-RM93F
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Enoplea > Dorylaimia > Trichinellida > Trichuridae > Trichuris

Accessions

  • Primary accession
    A0A085NLD8

Proteomes

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain548-691PI-PLC Y-box
Domain692-819C2
Region1016-1045Disordered
Compositional bias1022-1045Polar residues
Coiled coil1165-1193

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,218
  • Mass (Da)
    139,079
  • Last updated
    2014-10-29 v1
  • Checksum
    E13879E395D07EE5
MNKRPDFQWQVPVPELLLRGAYFDRLDEDSGTFEPKCFFRVDDLGFYLYWQVDGKVEAQTLDLIHISDVRLGGFPKVSSDYRNLVSLQRKGNLKETKVQCDVECRAASKEELDERSLTLVSGTDLVNVSFSYLLAEKRSDAQRQCERQNPSEEVNYRNSLPLTTNHFRSITRTFASGKTEKMVMQCMVELGLCEGKICPRQDVLEIFNNLCEQGQPYMTVERLVHFVNERDPRLNEILYPACDKPKATNLISKYEPLEENVKLGRMSYSGFLRFLISEDSAPMLFKRITLSQDMDQPLSHYLINSSHNTYLVGRQFGGRSSVEMYRQVLLAGCRCLELDCWDGTSGAGKDEPIITHGKAMCTDILFKDVIMAIKESAFVTSDYPVILSFENHCSKKNQLKMAKYCMEIFGDLLLSKPLPSNPLKPSCPLPSPNQLKRKILIKSKRLSPDVEQRQLEQFLLLGQLEEDTEEVAENPDVIGDTDSEAAALTPDNVAHPEEKSTEATSLRNKIRSIASPRIKDVILSKEEEERLFAQYHYTSATTNIHPLLSSLVNYTHPVKFGGFDVAEQADCHFHMSSFSESTGLGYLKTSAIELVKYDLPLAASGVCVHVYIFSSYNKRQMSRIYPKGGRVDSSNYLPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGNCGSGFCPERRYLLKPDFMRRPNRIFDPFSESPVDGVVAAYCSIRVISGQFLSDKKIGTYVEVEMYGLPTDTIRKEFKTKLVPANGLNPIYNQEPFVFRKVVLPELAVLRFAVYDENGKLLGQRILPLDGLQPGYRHISLRTEINFPMTLPTLFCHIVLKTYIPEGLGGSQSLADLPSSSKQFLKNHFADIVEALSDPKSYLATLENREKQMEHMGIRKEDIDEVPDRQLCAKVSSPDSDKVFSERSETPSSSIKNLTSRSTVKVVKDADVLEMIKLVTVEELQREKAFTKLTKKHQKEYQCLKHRHVKQRLEMQRQQTVSFEKLAKGKSQNALAKELRQSFPRLHDGHTSPLTITKSLDGTAPPTSNGLDDRSSVVSCSQASLIRQTVVLQTRDWSDLIKRQLELEHSLRKAHLEEEWALIKKLLIRTHQEQRASVKLQLETEFKQLRQRQTKKSMDDSKAIQLDKNVKKKAEKDRRVKEIQEKNCKIFLEERRRLALKHRRQEEILINLQEEQMQQVEKEAVGAVDLEEQVYLEALLAVKPETLV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1022-1045Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KL367489
EMBL· GenBank· DDBJ
KFD70284.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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