A0A085NLD8 · A0A085NLD8_9BILA
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1218 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Enoplea > Dorylaimia > Trichinellida > Trichuridae > Trichuris
Accessions
- Primary accessionA0A085NLD8
Proteomes
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 548-691 | PI-PLC Y-box | ||||
Sequence: LSSLVNYTHPVKFGGFDVAEQADCHFHMSSFSESTGLGYLKTSAIELVKYDLPLAASGVCVHVYIFSSYNKRQMSRIYPKGGRVDSSNYLPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGNCGSGFCPERRYLLKPDFMR | ||||||
Domain | 692-819 | C2 | ||||
Sequence: RPNRIFDPFSESPVDGVVAAYCSIRVISGQFLSDKKIGTYVEVEMYGLPTDTIRKEFKTKLVPANGLNPIYNQEPFVFRKVVLPELAVLRFAVYDENGKLLGQRILPLDGLQPGYRHISLRTEINFPM | ||||||
Region | 1016-1045 | Disordered | ||||
Sequence: LHDGHTSPLTITKSLDGTAPPTSNGLDDRS | ||||||
Compositional bias | 1022-1045 | Polar residues | ||||
Sequence: SPLTITKSLDGTAPPTSNGLDDRS | ||||||
Coiled coil | 1165-1193 | |||||
Sequence: RRRLALKHRRQEEILINLQEEQMQQVEKE |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,218
- Mass (Da)139,079
- Last updated2014-10-29 v1
- ChecksumE13879E395D07EE5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1022-1045 | Polar residues | ||||
Sequence: SPLTITKSLDGTAPPTSNGLDDRS |