A0A085N178 · A0A085N178_9BILA
- ProteinMetalloendopeptidase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1911 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | serine-type endopeptidase activity | |
Molecular Function | transmembrane transporter activity | |
Molecular Function | zinc ion binding | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMetalloendopeptidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Enoplea > Dorylaimia > Trichinellida > Trichuridae > Trichuris
Accessions
- Primary accessionA0A085N178
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1316-1337 | Helical | ||||
Sequence: FSSTPSAVSLIFSLQSSFYYFA | ||||||
Transmembrane | 1357-1379 | Helical | ||||
Sequence: GALLCAAGFFLSTFATSITYLYF | ||||||
Transmembrane | 1436-1456 | Helical | ||||
Sequence: LATAISLCGAGAGTFIMPPII | ||||||
Transmembrane | 1468-1486 | Helical | ||||
Sequence: VMLLIAGIQLHNLVFAALY | ||||||
Transmembrane | 1676-1698 | Helical | ||||
Sequence: YLLFTICYVLSTIGFFVPFLYLP | ||||||
Transmembrane | 1710-1729 | Helical | ||||
Sequence: MGSFLVSIIGIVNTFCRILW | ||||||
Transmembrane | 1741-1761 | Helical | ||||
Sequence: MHMINCANLVAGTSTVVLPYL | ||||||
Transmembrane | 1767-1788 | Helical | ||||
Sequence: LVAYCVFFGAGIASLISQRSVA | ||||||
Transmembrane | 1800-1824 | Helical | ||||
Sequence: IALGSIMMCMGFACLGGQPLAGYLF | ||||||
Transmembrane | 1830-1851 | Helical | ||||
Sequence: YNAAFGVSGGLMVMAGILGFSL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MTWSTFGQLTLLVTLTGCSLWSLYNA | ||||||
Chain | PRO_5005106222 | 27-1911 | Metalloendopeptidase | |||
Sequence: KKWTTEELLNSRFPYLSSNDLYLDVSKAGGFIADIVLSREDVEAIRMLRNNSLRRANHRHPSIISSGAPCHQCFAVKGHVIGKECEHFDLPALFSSFPAITTRTIGDAIAAPQLVVPSAFGSMESFRTKFWRTLAVGGGGNRFSSRNHSSLGDHHALFRRAMNHWENYTCVSFVPRTSEDVSYIVFTIAECGCCSFVGKRGEGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDLYVDIFYKNIQQGQDYNFEKLKPSEVNSLGQSYDFASIMHYARDTFSRAMYLDTILPKPDSSTHERPEIGQRIRLSPGDIIQTNTLYKCAKCGQTFHEASGIFSSPDYDNKVKSQGEPIHCEWRINTARGHHILLNFTYISIPDSVDCSGDSFLEVRDGPYAKSPLIGRYCGKHVEPLIITSNSHRVWIQYHVAHASLEDAPKKNALKEKKKRRGFAANFEVICGGNITADNGVIENPNYPYDYTPNSDCVWYITVPEDYQVAVIFSMFQLEQHEDCIYDYVEFREGHADDGDVLARVCGYSLPNSIKSNSNKMRVRFGSDASVEKAGFSFNFIKEFDECKTTNHGCRHKCVNTLGGYRCECDIGYELHSDGKSCEDACGGYLKGENGSLTSPNFPNLYPNKKRCVWEIKAHSQYRIFLNFTHFDLEGVLTNCEYDYIKVTSVDGDGEVAKVHGQFCGRIAPQFLLTSETSHLRIEFVTDSSVQKSGFAAVYFTDRDECEVDNGGCEQICKNMIGSYVCECESGYILASDGHHCKEGGCKFELNAAFGQLTSPSYPEDYPNDKECIWHFVTTPGHRLQLDFIEFEIEPHQDCAYDRIELYDGSSIDSPSLGKYCGPKAPEKITSSKNELYMFFHSDSSVQRKGFQAHYTSVCGGTLRAERSVGYVYSHAMYGGSNYENRVACEWTLLAEEGMSVEIQFTNFELEEEVHCEYDYVEVYDGESENSMRLGRFCGNKLPSMFISSGSVLRVRFRADDTVTAKGFVYEYFLTDQLLEQVDCLLWCSSFPPECSCACVYVKLHAIHHLDRLPHGLTIDASSTLVEWCLRLPANNHQIATNGHCDDQAKEQQIYCLHGPTMVHGRHAAVECLTSNSSSISALSHSFSTLVEFKESSKQGLRLATKEFSDWFDEKDSHVTCHYSIPEDIEMQPCSDNMSNFSPISLQVHFVAHKSSPAFSSHFENGKLHNDSGVYDVEETVIIVPLQECDEKIKALMVDYDKTCTLREEELIAEALITPPDGGWGWVIVAALFANLLILDGVELSAGQALLPILTEHFSSTPSAVSLIFSLQSSFYYFAGPFSGALVNAFGCRCVALGGALLCAAGFFLSTFATSITYLYFTYGVLAEVVKSRQVFILSEIFEKQDCKEPLGKGTGMGAIFLCGLSTVSQYFESRRGLATAISLCGAGAGTFIMPPIITLLTEYYHWRHVMLLIAGIQLHNLVFAALYRNLTPTKKQVVEVERRLSVILSAEFNQNIESADEGKGRKQMESSETSDSSLKEKKYSTVAENGRVSPILHQKTQRALSVTAAPIERFTGRQMSLTVDLERAKVHDEQELRKLSYASIVTVNRPMNRFDSLYEGAIPDSTTAQSIKETVPVDRMAESIPRIMQKKRKRFSVVLRNVLRDTFSIRLFASPTYLLFTICYVLSTIGFFVPFLYLPSHAEMLGSSAEMGSFLVSIIGIVNTFCRILWGWVADRPSVDAMHMINCANLVAGTSTVVLPYLKFYPELVAYCVFFGAGIASLISQRSVALLKFVGMKNLTIALGSIMMCMGFACLGGQPLAGYLFEISGNYNAAFGVSGGLMVMAGILGFSLNKIHSWEISKMQAFDKPLSSSRKTAESSREAKSSSSSVVCRLRHMLKMKFAPLLCSKASV | ||||||
Disulfide bond | 217↔239 | |||||
Sequence: CGCCSFVGKRGEGPQAISIGKNC | ||||||
Disulfide bond | 219↔220 | |||||
Sequence: CC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 144-355 | Peptidase M12A | ||||
Sequence: SAFGSMESFRTKFWRTLAVGGGGNRFSSRNHSSLGDHHALFRRAMNHWENYTCVSFVPRTSEDVSYIVFTIAECGCCSFVGKRGEGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDLYVDIFYKNIQQGQDYNFEKLKPSEVNSLGQSYDFASIMHYARDTFSRAMYLDTILPKPDSSTHERPEIGQRIRLSPGDIIQTNTLYKCA | ||||||
Domain | 357-488 | CUB | ||||
Sequence: CGQTFHEASGIFSSPDYDNKVKSQGEPIHCEWRINTARGHHILLNFTYISIPDSVDCSGDSFLEVRDGPYAKSPLIGRYCGKHVEPLIITSNSHRVWIQYHVAHASLEDAPKKNALKEKKKRRGFAANFEVI | ||||||
Domain | 489-601 | CUB | ||||
Sequence: CGGNITADNGVIENPNYPYDYTPNSDCVWYITVPEDYQVAVIFSMFQLEQHEDCIYDYVEFREGHADDGDVLARVCGYSLPNSIKSNSNKMRVRFGSDASVEKAGFSFNFIKE | ||||||
Domain | 601-641 | EGF-like | ||||
Sequence: EFDECKTTNHGCRHKCVNTLGGYRCECDIGYELHSDGKSCE | ||||||
Domain | 644-760 | CUB | ||||
Sequence: CGGYLKGENGSLTSPNFPNLYPNKKRCVWEIKAHSQYRIFLNFTHFDLEGVLTNCEYDYIKVTSVDGDGEVAKVHGQFCGRIAPQFLLTSETSHLRIEFVTDSSVQKSGFAAVYFTD | ||||||
Domain | 804-916 | CUB | ||||
Sequence: CKFELNAAFGQLTSPSYPEDYPNDKECIWHFVTTPGHRLQLDFIEFEIEPHQDCAYDRIELYDGSSIDSPSLGKYCGPKAPEKITSSKNELYMFFHSDSSVQRKGFQAHYTSV | ||||||
Domain | 917-1033 | CUB | ||||
Sequence: CGGTLRAERSVGYVYSHAMYGGSNYENRVACEWTLLAEEGMSVEIQFTNFELEEEVHCEYDYVEVYDGESENSMRLGRFCGNKLPSMFISSGSVLRVRFRADDTVTAKGFVYEYFLT | ||||||
Domain | 1285-1856 | Major facilitator superfamily (MFS) profile | ||||
Sequence: VIVAALFANLLILDGVELSAGQALLPILTEHFSSTPSAVSLIFSLQSSFYYFAGPFSGALVNAFGCRCVALGGALLCAAGFFLSTFATSITYLYFTYGVLAEVVKSRQVFILSEIFEKQDCKEPLGKGTGMGAIFLCGLSTVSQYFESRRGLATAISLCGAGAGTFIMPPIITLLTEYYHWRHVMLLIAGIQLHNLVFAALYRNLTPTKKQVVEVERRLSVILSAEFNQNIESADEGKGRKQMESSETSDSSLKEKKYSTVAENGRVSPILHQKTQRALSVTAAPIERFTGRQMSLTVDLERAKVHDEQELRKLSYASIVTVNRPMNRFDSLYEGAIPDSTTAQSIKETVPVDRMAESIPRIMQKKRKRFSVVLRNVLRDTFSIRLFASPTYLLFTICYVLSTIGFFVPFLYLPSHAEMLGSSAEMGSFLVSIIGIVNTFCRILWGWVADRPSVDAMHMINCANLVAGTSTVVLPYLKFYPELVAYCVFFGAGIASLISQRSVALLKFVGMKNLTIALGSIMMCMGFACLGGQPLAGYLFEISGNYNAAFGVSGGLMVMAGILGFSLNKIHS | ||||||
Region | 1517-1545 | Disordered | ||||
Sequence: SADEGKGRKQMESSETSDSSLKEKKYSTV |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,911
- Mass (Da)213,214
- Last updated2014-10-29 v1
- ChecksumBB1550B93B99C8D2