A0A084WPF6 · A0A084WPF6_ANOSI

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site284Nucleophile
Active site368
Active site370

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondihydroorotase activity
Molecular Functionmetal ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processcitrulline biosynthetic process
Biological Processglutamine metabolic process
Biological ProcessUTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • AGAP000300-PA-like protein

Gene names

    • ORF names
      ZHAS_00020388

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A084WPF6

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-23Disordered
Domain548-740ATP-grasp
Domain1083-1274ATP-grasp
Domain1339-1498MGS-like
Compositional bias1873-1887Polar residues
Region1873-1892Disordered
Region1939-1971Disordered
Compositional bias1947-1970Polar residues

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,279
  • Mass (Da)
    251,562
  • Last updated
    2014-10-29 v1
  • MD5 Checksum
    97FBAE9FA7BD6D8A6B7E6EB99EE12BE9
MDLQSKELVPPVAKGVAPEKDGGEYRTKTASLVLEDGTILHGHPFGATGDVDGEVVFQTGMVGYPESMTDPSYHGQILVLTYPLIGNYGIPDADLDECGLMRHFESNNRIWTAGLVVGEICEEPSHWRSKLTLSEWMAKHGVPGISGIDTRALTKKIREHGTVLGKIVQSRVETIAGFSFKNQNLRNLVKEVSLAQPMTYNESGSPRICAIDCGLKLNQVRCFVQRGARVDVMPWNARPNPADYDGLFLSNGPGDPEMCREVVDNLQWVLQDSGDTIKPIFGICLGHQILATAAGCRTFKMRYGNRGHNLPCMHRGTRRCYMTSQNHGFAVDSAEMPTGWEELFTNLNDGTNEGLVHESKPYFSVQFHPEHTAGPADLEVLFDVFLELVRECKAGGVVPSVRERLNDRLRFTPPVPVDLERPKKVLILGSGGLSIGQAGEFDYSGSQAIKALKEERIQTVLINPNIATVQTSKGLADKVYFLPLTVEYVEQVIKAERPGGVLLTFGGQTALNCGVELERAGVFSRYGIRILGTPIRSIIETEDRKLFAERVAEIGERVAPSAAVYSLGEALEAAERIGYPVMARAAFSLGGLGSGFASNADELRTLASHALAHSSQLIIDKSLKGWKEVEYEVVRDAYDNCITVCNMENVDPLGIHTGESIVVAPSQTLSNREYNMLRTTAIRVIRHFGVVGECNIQYALCPESEEYYIIEVNARLSRSSALASKATGYPLAYVAAKLALAVPLPDIRNSVTGVTTACFEPSLDYCVVKMPRWDLAKFARVSKNIGSSMKSVGEVMAIGRTFEEAFQKALRMVDSVNGFDPYLKPVNEQELREPTDKRMFVLAAALRAGYTVEQLYELTKIDRWFLRKLRGIIDFTVRLEGVGDGVQDLRVGLLREAKRLGFSDRMIAQCVKSTELAVRTVRKELGVLPFVKQIDTVAGEWPAATNYLYLTYSASENDVDFPGQYTMVIGSGVYRIGSSVEFDWCAVGCLRELRNLGRKTIMVNYNPETVSTDYDMCDRLYFEEISFEVVMDIYDSEQPEGVILSMGGQLPNNIAMDLHRQQARILGTSPESVDSAENRFKFSRLLDRKGILQPRWKELTNLQSAIAFCEEVGYPCLVRPSYVLSGAAMNVAYSNQDLETYLQHASDVSKEHPVVISKFLVEAKEIDVDAVAADGEILCMAVSEHVENAGVHSGDATLVTPPQDINRETLERIKEIARDIAALLDVTGPFNMQLIAKNNELKVIECNVRVSRSFPFVSKTLDHDFVALATRVIVGLAVEPVDVMRGCGRVGVKVPQFSFARLAGADVQLGVEMASTGEVACFGDNRYEAYLKAMMSTGFQIPKKSILLSIGSYKHKMELLPAIRILDKMGYKLYASMGTGDFYTEHGVAVESVQWTFDSLATDDNGGPPGNELRHLAEYLSNKQFDLVINLPMSGGGARRVSCFMTHGYRTRRLAVDYSIPLVTDVKCAKLLVEAMRRIGGAPPMKTHTDCISSRRMVKLPGFIDVHVHLREPGATHKETFATGTAAALAGGITMVLAMPNTQPAIVDRAALQLAQELAAKGARCDYALYVGASSGNYGNVHELASQAAALKMYLNETFTTLRLNGMLVWRAHLANWPKRAPLCVHAERETMAAVLLLASLADRPIHVCHVARKEEILVIKAAKERGIKVTCEVCPHHLFLSTADCERLGPGWAEVRPVLCSPEDQQALWDNLDVVDVFATDHAPHTRDEKQAGEKAPPGFPGLETILPLLLNAVSEGRLTLDDLVAKFHRNPRRIFNLPEQPNTYVEVDFDEEWTIPERPLHSKAHWTPFAGMRVKGCVHRVVLRGETAYVDGLVLVAPGYGQNVRDWPARRSTLTAGNSIEQINASLEALDTSLGSPSGPATSSVVRPSHDPAWFEPADGHTNDVFFRLLAHDPPASSGKQPTPATLGVHFAEQTPVRPVSPAPRTRCDSTSTSYVARGPTSETPTPRDRTLAGRHVLTVGMFTKEHLNEIFHLAQTMKARVAKDRPLDDLLRGKVMASIFYEVSTRTSCSFAAAMQRLGGRVVHIDETSSSARKGETLEDSIQVMAGYADVVVLRHPTPGAVERAAQHCRKPLINAGDGVGEHPTQALLDIFTIREEIGTVNGLTITMVGDLKHGRTVHSLARLLTLYNVNLRYVCPAGLEMPDRVKEFVDRKRISQRQFDSLEEAIAETDVLYMTRIQRERFASEQEYEKCCGQLVLTPHLMTVAKRRMIVMHPLPRVFEISPEIDNDPRAAYFRQAEYGMYVRMALLAMVLGRC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1873-1887Polar residues
Compositional bias1947-1970Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ATLV01025075
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KE525369
EMBL· GenBank· DDBJ
KFB52100.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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