A0A081LH88 · A0A081LH88_AERCA

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site785-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site1035-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site130-1385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site193uracil (UniProtKB | ChEBI)
Binding site198-200uracil (UniProtKB | ChEBI)
Binding site1995-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      C1C91_15920
      , HED45_11930
      , JC965_16780
      , KAM348_34130
      , KAM351_14760
      , KAM354_23930
      , KAM379_25590
      , N5I07_14260
      , N5I20_00950
      , N5J40_08655
      , OJY61_09925
      , P5S46_12980
      , WP2W18E01_16380

Organism names

  • Taxonomic identifier
  • Strains
    • T25-39
    • WP2-W18-ESBL-01
    • UFMG-H8
    • Aero21
    • KAM348
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Aeromonadales > Aeromonadaceae > Aeromonas

Accessions

  • Primary accession
    A0A081LH88

Proteomes

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    22,610
  • Last updated
    2014-10-29 v1
  • Checksum
    08B0E5A475EE6896
MKVVEVKHPLVKHKIGLMREGDISTKRFRELAKEVGSLLTYEATSDFETEKVTIDGWNGPVEVDQIKGKKVTVVPILRAGLGMMDGVLEHMPSARVSVVGIYRDEETLQPVPYFEKIVSNIEERLALVIDPMLATGGSMIATIDLLKKKGCQSIKVLVLVAAPEGIKALEAAHPDVELFCASIDQGLNEKGYIVPGLGDAGDKIFGTK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP025706
EMBL· GenBank· DDBJ
AXB06289.1
EMBL· GenBank· DDBJ
Genomic DNA
AP021927
EMBL· GenBank· DDBJ
BBQ30056.1
EMBL· GenBank· DDBJ
Genomic DNA
BPNL01000047
EMBL· GenBank· DDBJ
GJA55990.1
EMBL· GenBank· DDBJ
Genomic DNA
BPNN01000016
EMBL· GenBank· DDBJ
GJA62865.1
EMBL· GenBank· DDBJ
Genomic DNA
BPNQ01000044
EMBL· GenBank· DDBJ
GJA77157.1
EMBL· GenBank· DDBJ
Genomic DNA
BPOM01000020
EMBL· GenBank· DDBJ
GJB73501.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCIZ010000002
EMBL· GenBank· DDBJ
MDH1503629.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCFT010000001
EMBL· GenBank· DDBJ
MDH1898699.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCJV010000001
EMBL· GenBank· DDBJ
MDH1994874.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAVMO010000005
EMBL· GenBank· DDBJ
NKD16799.1
EMBL· GenBank· DDBJ
Genomic DNA
CP065937
EMBL· GenBank· DDBJ
QQA59886.1
EMBL· GenBank· DDBJ
Genomic DNA
CP110176
EMBL· GenBank· DDBJ
UZC88197.1
EMBL· GenBank· DDBJ
Genomic DNA
CP120942
EMBL· GenBank· DDBJ
WFF96582.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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