A0A081LH88 · A0A081LH88_AERCA
- ProteinUracil phosphoribosyltransferase
- Geneupp
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids208 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Catalytic activity
- diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil
Cofactor
Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.
Activity regulation
Allosterically activated by GTP.
Pathway
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 78 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 103 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 130-138 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: DPMLATGGS | ||||||
Binding site | 193 | uracil (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 198-200 | uracil (UniProtKB | ChEBI) | ||||
Sequence: GDA | ||||||
Binding site | 199 | 5-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | GTP binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | uracil phosphoribosyltransferase activity | |
Biological Process | UMP salvage | |
Biological Process | uracil salvage |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUracil phosphoribosyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Aeromonadales > Aeromonadaceae > Aeromonas
Accessions
- Primary accessionA0A081LH88
Proteomes
Structure
Sequence
- Sequence statusComplete
- Length208
- Mass (Da)22,610
- Last updated2014-10-29 v1
- Checksum08B0E5A475EE6896
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP025706 EMBL· GenBank· DDBJ | AXB06289.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP021927 EMBL· GenBank· DDBJ | BBQ30056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BPNL01000047 EMBL· GenBank· DDBJ | GJA55990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BPNN01000016 EMBL· GenBank· DDBJ | GJA62865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BPNQ01000044 EMBL· GenBank· DDBJ | GJA77157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BPOM01000020 EMBL· GenBank· DDBJ | GJB73501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCIZ010000002 EMBL· GenBank· DDBJ | MDH1503629.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCFT010000001 EMBL· GenBank· DDBJ | MDH1898699.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCJV010000001 EMBL· GenBank· DDBJ | MDH1994874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAVMO010000005 EMBL· GenBank· DDBJ | NKD16799.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP065937 EMBL· GenBank· DDBJ | QQA59886.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP110176 EMBL· GenBank· DDBJ | UZC88197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP120942 EMBL· GenBank· DDBJ | WFF96582.1 EMBL· GenBank· DDBJ | Genomic DNA |