A0A077M4H0 · A0A077M4H0_9MICO

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site74substrate
Binding site211-213substrate
Binding site264substrate
Binding site265-270GTP (UniProtKB | ChEBI)
Active site266
Binding site392-394substrate
Binding site394GTP (UniProtKB | ChEBI)
Binding site425GTP (UniProtKB | ChEBI)
Binding site519-522GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      BN12_3980003

Organism names

  • Taxonomic identifier
  • Strain
    • T1-X7
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Intrasporangiaceae > Nostocoides

Accessions

  • Primary accession
    A0A077M4H0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-231Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain238-604Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    620
  • Mass (Da)
    68,001
  • Last updated
    2014-10-29 v1
  • Checksum
    E81CCEDC3FE3E2D0
MADIETAFEHSGLGNPHVREFVRHWAGITGAARVEVVSAADDGRLIEEALAAGEIFPAGEGRYYSRSYPKDTARSEERTIVATSNPADKGVYDNWRPSSEMKPLLERQMSGASAGKTMYVVPYLMAPPGSPLHAYAVGVELTDSRPVVLHMIRMARVGVEHVEGLEDPSMFVRAVHVTGDLPAMQHGTPDDQRYFVTVADERTILHYGSSYGGNALLGKIAHGLRQAAYDGYASGKFLGEQFMLIGIEDRVAGRTWHICGGFPSASGKTNLAMMLPPDALGDRYRVFFYGDDIAWLWVNPDDGRLYGLNPEFGVFGVAKDTNEKTNPTALESVGPGTGAIFTNVAYNPDTQEVWWEGRTPEPPADVAGWLDWKGEPIADRPEGSTEPWSHPNSRFTTTLANVPNIAPDYESPAGVPIDGIIFGGRTRDREPLIRAITDLAEGVYDGLTLGAEATFAAEGVDGQLRYDPMSMRPFMSYPEGPYAAQWLSIVGAASEQPIFAHVNWFQRDPEDGHFLWPGYRENLRPLLWLMRLKDGTVTGRSTPVGILPTEEELDLEGVDITPADLETVLSIDVERWRQEMGFRQAHLEQFDGLPEAIWAAHRRVAAALESADVDTAATPG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJB01000332
EMBL· GenBank· DDBJ
CCH79020.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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