A0A077LSJ4 · A0A077LSJ4_9CALI

Function

function

Capsid protein VP60 self assembles to form an icosahedral capsid with a T=3 symmetry, about 35 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins assembled as icosahedron with T=1 symmetry. The capsid encapsulate VP2 proteins and genomic or subgenomic RNA. Attaches virion to target cells by binding histo-blood group antigens, inducing endocytosis of the viral particle. Acidification of the endosome induces conformational change of capsid protein thereby injecting virus genomic RNA into host cytoplasm.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component

Names & Taxonomy

Protein names

  • Submitted names
    • Capsid protein

Gene names

    • Name
      VP60

Organism names

  • Taxonomic identifier
  • Strain
    • 0323
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Lagovirus

Accessions

  • Primary accession
    A0A077LSJ4

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-32Disordered
Domain9-293Calicivirus coat protein

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    576
  • Mass (Da)
    60,030
  • Last updated
    2014-10-29 v1
  • MD5 Checksum
    73EBF0B4B48510A787FB68644181DA14
MEGKPRAEAPGTATTASVPGTTTDGMDPGVTASTDVVTADNVAASVATAGIGGPPQQASPQESWRVNFFYNDVFTWSVTDAPGSILYTVQHSPQNNPFTQVLSQMYAGWAGGMQFRFIVAGSGIFGGRLVCAIIPPGIQIQPGLEVRQFPHVVIDARSLEPVTITMPDLRPEMYHPTGDPGLVPTLVVSVYNNLINPFGGTTSSIQVTVETRPSEDFEFVLIRAPSSKTVDSVNPSWLLTTPVLTGAGSDNRWGAPIVGLQPVPGGFSTSNRHWNMNGETYGWSSPRFDDIDHPSGNVSYPTGSATNTIATWYASAGTATTNPISSVAPDGFPDMGAIPFSGSNIPTGAWVGFGQVWNASSGAPFVGTAQAYELGFANGAPSNIRPVTTTTGAQLVAKSIYGVAIGTNQTSAGILFLSKGMVSTSGVAATTYTPQPSAIVTTPGTPVAAPIGKNTPIMFSAVVRRTGDMNAGPGSDNGTQYGVGSQPLSVTLGLSLTNYSSALQPGQFFVWQLNFASGFMEVGMNTDGYFYAGTGTYSGMIELTDLIDVRPVGVRPNTSTLVFNFAGVATTGYSYV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN689419
EMBL· GenBank· DDBJ
CBK55551.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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