A0A076JDT4 · A0A076JDT4_9MUSC
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids511 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Opomyzoidea > Agromyzidae > Phytomyzinae > Liriomyza
Accessions
- Primary accessionA0A076JDT4
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-35 | Helical | ||||
Sequence: DIGTLYFMFGAWAGMVGTSLSILI | ||||||
Transmembrane | 55-81 | Helical | ||||
Sequence: IVTAHAFIMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 102-124 | Helical | ||||
Sequence: LLPPALTLLLMSSMVENGAGTGW | ||||||
Transmembrane | 144-169 | Helical | ||||
Sequence: AIFSLHLAGISSILGAVNFITTIINM | ||||||
Transmembrane | 181-208 | Helical | ||||
Sequence: LFVWSVLITAILLLLSLPVLAGAITMLL | ||||||
Transmembrane | 228-249 | Helical | ||||
Sequence: LYQHLFWFFGHPEVYILILPGF | ||||||
Transmembrane | 270-289 | Helical | ||||
Sequence: GMIYAMLAIGLLGFIVWAHH | ||||||
Transmembrane | 301-325 | Helical | ||||
Sequence: AYFTSATMIIAVPTGIKIFSWLATL | ||||||
Transmembrane | 337-357 | Helical | ||||
Sequence: LWSLGFVFLFTVGGLTGVVLA | ||||||
Transmembrane | 377-398 | Helical | ||||
Sequence: YVLSMGAVFAIMAGFIHWYPLF | ||||||
Transmembrane | 410-428 | Helical | ||||
Sequence: SQFFIMFIGVNLTFFPQHF | ||||||
Transmembrane | 448-471 | Helical | ||||
Sequence: WNVISTIGSSISLLGIILFLYIIW |
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-510 | Cytochrome oxidase subunit I profile | ||||
Sequence: MRQWLFSTNHKDIGTLYFMFGAWAGMVGTSLSILIRAELGHPGALIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALTLLLMSSMVENGAGTGWTVYPPLSSIIAHGGASVDLAIFSLHLAGISSILGAVNFITTIINMRSTGITFDRMPLFVWSVLITAILLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISHESGKKETFGSLGMIYAMLAIGLLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLSYTPTTLWSLGFVFLFTVGGLTGVVLANSSIDVVLHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLFTGLSLNVKLLKSQFFIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTAWNVISTIGSSISLLGIILFLYIIWESMMTQRQVIFPIQLNSSIEWYQNTPPAEHSYSELPMLT |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length511
- Mass (Da)56,581
- Last updated2014-10-29 v1
- Checksum9CCFA799C4AD4511
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KJ778702 EMBL· GenBank· DDBJ | AII71796.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778703 EMBL· GenBank· DDBJ | AII71798.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778706 EMBL· GenBank· DDBJ | AII71804.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778707 EMBL· GenBank· DDBJ | AII71806.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778708 EMBL· GenBank· DDBJ | AII71808.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778709 EMBL· GenBank· DDBJ | AII71810.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778710 EMBL· GenBank· DDBJ | AII71812.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778711 EMBL· GenBank· DDBJ | AII71814.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778712 EMBL· GenBank· DDBJ | AII71816.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778713 EMBL· GenBank· DDBJ | AII71818.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778716 EMBL· GenBank· DDBJ | AII71824.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778717 EMBL· GenBank· DDBJ | AII71826.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778718 EMBL· GenBank· DDBJ | AII71828.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778719 EMBL· GenBank· DDBJ | AII71830.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778721 EMBL· GenBank· DDBJ | AII71834.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778722 EMBL· GenBank· DDBJ | AII71836.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778723 EMBL· GenBank· DDBJ | AII71838.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778724 EMBL· GenBank· DDBJ | AII71840.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778725 EMBL· GenBank· DDBJ | AII71842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778726 EMBL· GenBank· DDBJ | AII71844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778727 EMBL· GenBank· DDBJ | AII71846.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778728 EMBL· GenBank· DDBJ | AII71848.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778729 EMBL· GenBank· DDBJ | AII71850.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778730 EMBL· GenBank· DDBJ | AII71852.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778731 EMBL· GenBank· DDBJ | AII71854.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778732 EMBL· GenBank· DDBJ | AII71856.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778733 EMBL· GenBank· DDBJ | AII71858.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778734 EMBL· GenBank· DDBJ | AII71860.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778736 EMBL· GenBank· DDBJ | AII71864.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778737 EMBL· GenBank· DDBJ | AII71866.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778738 EMBL· GenBank· DDBJ | AII71868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778739 EMBL· GenBank· DDBJ | AII71870.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778740 EMBL· GenBank· DDBJ | AII71872.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778741 EMBL· GenBank· DDBJ | AII71874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778742 EMBL· GenBank· DDBJ | AII71876.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778744 EMBL· GenBank· DDBJ | AII71880.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778745 EMBL· GenBank· DDBJ | AII71882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778747 EMBL· GenBank· DDBJ | AII71886.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778748 EMBL· GenBank· DDBJ | AII71888.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778749 EMBL· GenBank· DDBJ | AII71890.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778750 EMBL· GenBank· DDBJ | AII71892.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ778751 EMBL· GenBank· DDBJ | AII71894.1 EMBL· GenBank· DDBJ | Genomic DNA |