A0A076JDT4 · A0A076JDT4_9MUSC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processoxidative phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Lang1
    • Lang10
    • Lang11
    • Lang12
    • Lang14
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Opomyzoidea > Agromyzidae > Phytomyzinae > Liriomyza

Accessions

  • Primary accession
    A0A076JDT4

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-35Helical
Transmembrane55-81Helical
Transmembrane102-124Helical
Transmembrane144-169Helical
Transmembrane181-208Helical
Transmembrane228-249Helical
Transmembrane270-289Helical
Transmembrane301-325Helical
Transmembrane337-357Helical
Transmembrane377-398Helical
Transmembrane410-428Helical
Transmembrane448-471Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-510Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    511
  • Mass (Da)
    56,581
  • Last updated
    2014-10-29 v1
  • Checksum
    9CCFA799C4AD4511
MRQWLFSTNHKDIGTLYFMFGAWAGMVGTSLSILIRAELGHPGALIGDDQIYNVIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPALTLLLMSSMVENGAGTGWTVYPPLSSIIAHGGASVDLAIFSLHLAGISSILGAVNFITTIINMRSTGITFDRMPLFVWSVLITAILLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISHESGKKETFGSLGMIYAMLAIGLLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQLSYTPTTLWSLGFVFLFTVGGLTGVVLANSSIDVVLHDTYYVVAHFHYVLSMGAVFAIMAGFIHWYPLFTGLSLNVKLLKSQFFIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTAWNVISTIGSSISLLGIILFLYIIWESMMTQRQVIFPIQLNSSIEWYQNTPPAEHSYSELPMLTN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ778702
EMBL· GenBank· DDBJ
AII71796.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778703
EMBL· GenBank· DDBJ
AII71798.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778706
EMBL· GenBank· DDBJ
AII71804.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778707
EMBL· GenBank· DDBJ
AII71806.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778708
EMBL· GenBank· DDBJ
AII71808.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778709
EMBL· GenBank· DDBJ
AII71810.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778710
EMBL· GenBank· DDBJ
AII71812.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778711
EMBL· GenBank· DDBJ
AII71814.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778712
EMBL· GenBank· DDBJ
AII71816.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778713
EMBL· GenBank· DDBJ
AII71818.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778716
EMBL· GenBank· DDBJ
AII71824.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778717
EMBL· GenBank· DDBJ
AII71826.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778718
EMBL· GenBank· DDBJ
AII71828.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778719
EMBL· GenBank· DDBJ
AII71830.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778721
EMBL· GenBank· DDBJ
AII71834.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778722
EMBL· GenBank· DDBJ
AII71836.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778723
EMBL· GenBank· DDBJ
AII71838.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778724
EMBL· GenBank· DDBJ
AII71840.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778725
EMBL· GenBank· DDBJ
AII71842.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778726
EMBL· GenBank· DDBJ
AII71844.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778727
EMBL· GenBank· DDBJ
AII71846.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778728
EMBL· GenBank· DDBJ
AII71848.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778729
EMBL· GenBank· DDBJ
AII71850.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778730
EMBL· GenBank· DDBJ
AII71852.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778731
EMBL· GenBank· DDBJ
AII71854.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778732
EMBL· GenBank· DDBJ
AII71856.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778733
EMBL· GenBank· DDBJ
AII71858.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778734
EMBL· GenBank· DDBJ
AII71860.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778736
EMBL· GenBank· DDBJ
AII71864.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778737
EMBL· GenBank· DDBJ
AII71866.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778738
EMBL· GenBank· DDBJ
AII71868.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778739
EMBL· GenBank· DDBJ
AII71870.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778740
EMBL· GenBank· DDBJ
AII71872.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778741
EMBL· GenBank· DDBJ
AII71874.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778742
EMBL· GenBank· DDBJ
AII71876.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778744
EMBL· GenBank· DDBJ
AII71880.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778745
EMBL· GenBank· DDBJ
AII71882.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778747
EMBL· GenBank· DDBJ
AII71886.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778748
EMBL· GenBank· DDBJ
AII71888.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778749
EMBL· GenBank· DDBJ
AII71890.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778750
EMBL· GenBank· DDBJ
AII71892.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ778751
EMBL· GenBank· DDBJ
AII71894.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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