A0A076EKN4 · A0A076EKN4_RHOOP

Function

function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.

Features

Showing features for site, active site, binding site.

TypeIDPosition(s)Description
Site106Transition state stabilizer
Active site110Proton acceptor
Binding site272Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncatalase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processcellular response to hydrogen peroxide
Biological Processhydrogen peroxide catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Catalase-peroxidase
  • EC number
  • Short names
    CP
  • Alternative names
    • Peroxidase/catalase

Gene names

    • Name
      katG
    • ORF names
      EP51_14825

Organism names

Accessions

  • Primary accession
    A0A076EKN4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link231↔257Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-109)

Post-translational modification

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-24Polar residues
Region1-42Disordered
Domain143-418Plant heme peroxidase family profile

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    742
  • Mass (Da)
    81,260
  • Last updated
    2014-10-29 v1
  • Checksum
    8E9F27BAD16D5D42
MSDSCPVAHEGNTQSTSESENPVIPSPTPAAHRPRSNRDWWPNQPELSVLHAHTSKSNPMGEDFVYAEEFAKLDVEALKRDVIDLMTTSQDWWPADYGHYGGLFIRLSWHAAGTYRIADGRGGGGQGAQRFAPLNSWPDNASLDKARRLLWPVKQKYGKQISWADLLVFVGNCALESMGFKTFGFGFGREDIWEPEEMYWGPEDTWLGDERYSGDRELSGPLGAVQMGLIYVNPEGPNGQPDPLAAARDIRETFGRMAMNDVETAALIAGGHTFGKTHGAGDADLVGPEPEGAPIEQQGLGWKSAYGTGVGKDAITSGLEVVWTPTPTKWDNSFLEVLYGYEWELTKSPAGAWQWTAKDGAGAGTIPDPFDSSAGRAPTMLTTDLSLRIDPAYEKITRRWLDHPEEFAEEFAKAWYKLLHRDMGPVTRYLGPWVPEAQLWQDPVPAVDHQLIGDSEIAALKGKILDSGLSISQLVSTAWASAATHRSTDMRGGANGARIRLAPQKDWEINNPTELATVLQTLEQIQQDFNSSQSGGVKVSLADLIVLAGAAAVEKAAKNAGQDVTVPFTPGRTDATQEQTDVESFAVLEPRADGFRNYLREGEKLPAEALLVDRAYMLNLTAPEMTVLVGGLRALNANFGQTKHGVFTDRPEALTNDFFVNLLDMGTQWKGAASAENVYEGTDRVTGDAKWTATAVDLVFGSNSQLRALAEVYATDDAQQKFVQDFVSAWNKVMNLDRFDLD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-24Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP008947
EMBL· GenBank· DDBJ
AII05792.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp