A0A076EGR5 · A0A076EGR5_RHOOP

Function

function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.

Features

Showing features for binding site.

118120406080100120140160180
TypeIDPosition(s)Description
Binding site10-15ATP (UniProtKB | ChEBI)
Binding site31AMP (UniProtKB | ChEBI)
Binding site36AMP (UniProtKB | ChEBI)
Binding site57-59AMP (UniProtKB | ChEBI)
Binding site85-88AMP (UniProtKB | ChEBI)
Binding site92AMP (UniProtKB | ChEBI)
Binding site127ATP (UniProtKB | ChEBI)
Binding site129AMP (UniProtKB | ChEBI)
Binding site140AMP (UniProtKB | ChEBI)
Binding site166ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular Functionnucleoside diphosphate kinase activity
Biological ProcessAMP salvage
Biological Processnucleoside diphosphate metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase
  • EC number
  • Short names
    AK
  • Alternative names
    • ATP-AMP transphosphorylase
    • ATP:AMP phosphotransferase
    • Adenylate monophosphate kinase

Gene names

    • Name
      adk
    • ORF names
      C5613_00295
      , EP51_09845

Organism names

Accessions

  • Primary accession
    A0A076EGR5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region30-59NMP

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    181
  • Mass (Da)
    19,508
  • Last updated
    2014-10-29 v1
  • Checksum
    24F8E69EA798518F
MRLVLLGPPGAGKGTQAAILSEKLGVPHISTGDLFRANIGQATPLGLEAKKYLDAGDLVPSEITNNMVKARVGEPDAANGFLLDGFPRTVDQAQALEAILAELNTKLDAVLSFIVDEDVVVERMLARGRADDKEDVIRNRLRVYREETAPLLDYYKDQLVTVDALGEVDEVNARALAALGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP008947
EMBL· GenBank· DDBJ
AII04891.1
EMBL· GenBank· DDBJ
Genomic DNA
PUIO01000001
EMBL· GenBank· DDBJ
PQP26769.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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