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A0A075GAE5 · A0A075GAE5_9EURY

Function

function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site51Mg2+ (UniProtKB | ChEBI)
Binding site51-523-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site903-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site90Mg2+ (UniProtKB | ChEBI)
Binding site1203-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site122Mg2+ (UniProtKB | ChEBI)
Active site189Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionmethyltransferase activity
Biological Processcoenzyme A biosynthetic process
Biological Processmethylation
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • EC number
  • Alternative names
    • Ketopantoate hydroxymethyltransferase
      (KPHMT
      )

Gene names

    • Name
      panB

Organism names

Accessions

  • Primary accession
    A0A075GAE5

Subcellular Location

Keywords

Interaction

Subunit

Homodecamer; pentamer of dimers.

Family & Domains

Sequence similarities

Belongs to the PanB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    271
  • Mass (Da)
    28,924
  • Last updated
    2014-10-29 v1
  • MD5 Checksum
    F08DD2A205D7D445A7AC066D2E7CE860
MAPASDARRITTNTLQAMKQDGEKIAMLTAYDYSLARLVDGAGVDVILVGDSASNVMAGNETTVPITLDQMIYHASGVVRGAQRALVVVDLPFGTYQGDSRTALESAIRIMKESGAHAVKLEGGAEVGESVERILTAGIPVMGHLGLTPQSIYKFGTYTVRAREKAEAQKLVADAKHLEQAGCFAIVLEKIPASLAKQVSASIAVPTIGIGAGPDCDGQVLVLHDMLGITQDFSPRFLRRYLDLEKDIQSAIAQYVGDVRGGEFPTERESY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF900610
EMBL· GenBank· DDBJ
AIF01041.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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