A0A075D615 · A0A075D615_APOCI

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 01981
    • 01983
    • 07065
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Geometroidea > Geometridae > Ennominae > Apocheima

Accessions

  • Primary accession
    A0A075D615

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-34Helical
Transmembrane54-80Helical
Transmembrane101-123Helical
Transmembrane143-168Helical
Transmembrane180-207Helical
Transmembrane227-255Helical
Transmembrane267-288Helical
Transmembrane300-323Helical
Transmembrane335-356Helical
Transmembrane376-397Helical
Transmembrane409-427Helical
Transmembrane447-470Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-509Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    510
  • Mass (Da)
    56,618
  • Last updated
    2014-10-29 v1
  • Checksum
    D91121995E116B12
RKWLYSTNHKDIGTLYFIFGIWAGMVGTSLSLLIRAELGNPGSLIGDDQIYNTIVTAHAFIMIFFMVMPIMIGGFGNWLVPLMLGAPDMAFPRMNNMSFWLLPPSITLLISSSIVENGAGTGWTVYPPLSSNIAHGGSSVDLAIFSLHLAGISSILGAINFITTIINMRLNNLSFDQMPLFVWSVGITAFLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGKKETFGCLGMIYAMMAIGILGFIVWAHHMFTVGMDIDTRAYFTSATMIIAVPTGIKIFSWLATLHGTQINYSPSILWSLGFVFLFTVGGLTGVVLANSSIDITLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWYPLFTGLSLNPYMLKIQFFIMFIGVNLTFFPQHFLGLAGMPRRYSDYPDSYISWNIVSSLGSYISLLAVILILIIIWESMINQRMILFSLNMSSNIEWLQNLPPAEHSYNELPIMSN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF836545
EMBL· GenBank· DDBJ
AHG99138.1
EMBL· GenBank· DDBJ
Genomic DNA
KR478686
EMBL· GenBank· DDBJ
ALI31067.1
EMBL· GenBank· DDBJ
Genomic DNA
KR478706
EMBL· GenBank· DDBJ
ALO20591.1
EMBL· GenBank· DDBJ
Genomic DNA
KR478707
EMBL· GenBank· DDBJ
ALO20598.1
EMBL· GenBank· DDBJ
Genomic DNA
KR478688
EMBL· GenBank· DDBJ
ALP86128.1
EMBL· GenBank· DDBJ
Genomic DNA
KR478689
EMBL· GenBank· DDBJ
ALP86137.1
EMBL· GenBank· DDBJ
Genomic DNA
KR478692
EMBL· GenBank· DDBJ
ALP86163.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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