A0A075C6F3 · A0A075C6F3_GEOBE
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids490 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Castorimorpha > Geomyidae > Geomys
Accessions
- Primary accessionA0A075C6F3
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 43-64 | Helical | |||
Transmembrane | 85-109 | Helical | |||
Transmembrane | 129-152 | Helical | |||
Transmembrane | 164-191 | Helical | |||
Transmembrane | 224-242 | Helical | |||
Transmembrane | 249-272 | Helical | |||
Transmembrane | 284-306 | Helical | |||
Transmembrane | 318-340 | Helical | |||
Transmembrane | 360-381 | Helical | |||
Transmembrane | 393-414 | Helical | |||
Transmembrane | 434-454 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Sequence
- Sequence statusFragment
- Length490
- Mass (Da)54,044
- Last updated2014-10-29 v1
- Checksum2A5D52F7FFC96A30
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 490 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KF542732 EMBL· GenBank· DDBJ | AGV29903.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542733 EMBL· GenBank· DDBJ | AGV29904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542734 EMBL· GenBank· DDBJ | AGV29905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542735 EMBL· GenBank· DDBJ | AGV29906.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542736 EMBL· GenBank· DDBJ | AGV29907.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542737 EMBL· GenBank· DDBJ | AGV29908.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542738 EMBL· GenBank· DDBJ | AGV29909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542739 EMBL· GenBank· DDBJ | AGV29910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542740 EMBL· GenBank· DDBJ | AGV29911.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF542741 EMBL· GenBank· DDBJ | AGV29912.1 EMBL· GenBank· DDBJ | Genomic DNA |