A0A075C6F3 · A0A075C6F3_GEOBE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Castorimorpha > Geomyidae > Geomys

Accessions

  • Primary accession
    A0A075C6F3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane43-64Helical
Transmembrane85-109Helical
Transmembrane129-152Helical
Transmembrane164-191Helical
Transmembrane224-242Helical
Transmembrane249-272Helical
Transmembrane284-306Helical
Transmembrane318-340Helical
Transmembrane360-381Helical
Transmembrane393-414Helical
Transmembrane434-454Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-490Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    490
  • Mass (Da)
    54,044
  • Last updated
    2014-10-29 v1
  • Checksum
    2A5D52F7FFC96A30
MIFGAWAGMVGTGLSILIRAELGQPGSLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAITQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTIGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFTGYTLNDTWAKIHFTIMFVGVNMTFFPQHFLGLAGMPRRYSDYPDAYTTWNTISSMGSFISLTAVILMIYMIWEALASKRLVKSVPLTSTNLEWMHGCPPPFHTFEEPV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue490

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KF542732
EMBL· GenBank· DDBJ
AGV29903.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542733
EMBL· GenBank· DDBJ
AGV29904.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542734
EMBL· GenBank· DDBJ
AGV29905.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542735
EMBL· GenBank· DDBJ
AGV29906.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542736
EMBL· GenBank· DDBJ
AGV29907.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542737
EMBL· GenBank· DDBJ
AGV29908.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542738
EMBL· GenBank· DDBJ
AGV29909.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542739
EMBL· GenBank· DDBJ
AGV29910.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542740
EMBL· GenBank· DDBJ
AGV29911.1
EMBL· GenBank· DDBJ
Genomic DNA
KF542741
EMBL· GenBank· DDBJ
AGV29912.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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