A0A075AYI1 · A0A075AYI1_ROZAC

  • Protein
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoskeleton
Cellular Componentcytosol
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Function5-diphosphoinositol pentakisphosphate 1-kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functioninositol hexakisphosphate 1-kinase activity
Molecular Functioninositol hexakisphosphate 3-kinase activity
Molecular Functioninositol hexakisphosphate 4-kinase activity
Molecular Functioninositol hexakisphosphate 5-kinase activity
Molecular Functioninositol hexakisphosphate 6-kinase activity
Molecular Functioninositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
Molecular Functioninositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
Molecular Functioninositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
Molecular Functionmetal ion binding
Biological Processinositol metabolic process
Biological Processinositol phosphate biosynthetic process
Biological Processinositol phosphate catabolic process
Biological Processintracellular phosphate ion homeostasis
Biological Processmitotic spindle assembly
Biological Processphosphorylation
Biological Processregulation of bipolar cell growth
Biological Processregulation of mitotic spindle elongation (spindle phase three)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
  • EC number

Gene names

    • ORF names
      O9G_000738

Organism names

Accessions

  • Primary accession
    A0A075AYI1

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain340-549ATP-grasp

Sequence similarities

Belongs to the histidine acid phosphatase family. VIP1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,042
  • Mass (Da)
    120,389
  • Last updated
    2014-10-01 v1
  • Checksum
    DDE1933D5B800656
MNGMPDMYAQALEESILQAASVVEAQIDEKIRELENADENSLESIRRQRIQQMKNAALQKAHWRSLGHGSYSELLSEKAFFEEGKKSKDLVCHFYRTSTFRCKILDRHLEALSKAHLEAKFVKIDAEKSPFLCERLGVRVLPTLVIVKDRKPVDQIVGFAEIGNNDDFETIALARRIAKSGVIRFEENEDYSEYGVMMNKNNFYGCVFRSSSLRKLIIGVCAMDTKARSKPMRNILDRITATSDFEVVIFGDKTILDDPIEEWPQCQFLISFFSKGFPLQKAIEYVALRRPFCINDLPLQQLLWDRRWVLSVLDAIDVPTPKRIIVNRDEGPKYYKGVIEELNKNLGIDLGNMTNFSRENVIQIDKDTIMVGKQRLEKPFVEKPVDGEDHNIYIYYPESMGGGVRKLFRKVGNKSSEFFPDEWEIRKEGSFIYETFIDVEKAEDIKVYTIGPYYAHAETRKSPVVDGIVRRNTDGKEVRHLTDLSEEEQELARRVSMAFGQTICGFDLVRCGSKSMVIDVNGWSFVKGNDNYYDMCAKIMSQTFLKIARKRRTTILKEPLNENQWKLKSFISIFRHADRTPKQKMKFNVSSAPFLDLIVKGKEETMIRNPDGLERIEKAAEASLSLGIEEKSKLLQLMEILSKKKKSPGTKVQIKPSYSKSREIEKAQLIVKWGGEFTHAGRHHSKDFGENLRKDLLLMNRKMIDDVKVYTSSERRVMATADIFSKALMFVAELPDDFLSIKKEMLDDNFDAKEKLDKIPENVQFLNVHPEFKNPRVTLDEVFITLKDLRQVMRSNFDTLDVDSLSHRWCCAESSILFKERWEKLFKDFCDVEINNFDPSKVSELYDSLKYDALHHREFFERIFVKNQNCPNEKAALADLIRKAKILFDFIAPQEFGLFPEEKVEIGKIIANRLLAQILDDLNEAKIHATDPCTRLYFTKESHVHALLNIVRFGGLECSIGNWDELDYLTQITFEVYERFKSNTSGFEYSIRIGFSPGAHDSNILDVQIDQKHALSVAPRRWITEHIPLDHAISIIEKMLNK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE560848
EMBL· GenBank· DDBJ
EPZ35342.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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