A0A074JCS5 · A0A074JCS5_9RHOB

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site7-12NAD+ (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site30NADPH (UniProtKB | ChEBI)
Binding site102NADPH (UniProtKB | ChEBI)
Binding site102sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site102substrate
Binding site130sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site132sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site134NAD+ (UniProtKB | ChEBI)
Binding site134NADPH (UniProtKB | ChEBI)
Active site183Proton acceptor
Binding site183sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site236sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site246sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site247NAD+ (UniProtKB | ChEBI)
Binding site247NADPH (UniProtKB | ChEBI)
Binding site247sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site247-248substrate
Binding site248sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site268NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      TP2_05275

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 10166
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Thioclava

Accessions

  • Primary accession
    A0A074JCS5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_500169469217-318Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-154Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain172-308Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    318
  • Mass (Da)
    32,553
  • Last updated
    2014-10-01 v1
  • Checksum
    C74EBFB47A94E5E6
MSIAVLGAGAFGTALAASLAQKGPVTLWARDPDQAKAMQTTRENTRRLAGVKLPANVSVTSEIASAFASDTLLLAMPMQQMAGFLNSHAETLTGKTLVSCSKGIDLATGQGPTGLIRSLVQGARAAVLTGPSFAADIARGLPTALTLACADHSEALQAELSTPTLRLYRTTDTTGAELGGALKNVYAIAAGTVIGAGLGDSARAALMTRGFAEMLRVALALGARAETLSGLSGFGDLVLTCTSEQSRNFRLGYALGSGAGFDAAITVEGVATAKALNALAERHQIEIPVAAMVNALTQQEISVSEAMQILLARPLKEE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AUND01000012
EMBL· GenBank· DDBJ
KEO54339.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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