A0A074J9A7 · A0A074J9A7_9RHOB

Function

function

Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 2 Zn2+ or Co2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site69Zn2+ 1 (UniProtKB | ChEBI)
Active site71
Binding site102Zn2+ 1 (UniProtKB | ChEBI)
Binding site102Zn2+ 2 (UniProtKB | ChEBI)
Active site135Proton acceptor
Binding site136Zn2+ 2 (UniProtKB | ChEBI)
Binding site164Zn2+ 1 (UniProtKB | ChEBI)
Binding site353Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncobalt ion binding
Molecular Functionsuccinyl-diaminopimelate desuccinylase activity
Molecular Functionzinc ion binding
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinyl-diaminopimelate desuccinylase
  • EC number
  • Short names
    SDAP desuccinylase
  • Alternative names
    • N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase

Gene names

    • Name
      dapE
    • ORF names
      TP2_04320

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 10166
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Thioclava

Accessions

  • Primary accession
    A0A074J9A7

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain177-276Peptidase M20 dimerisation

Sequence similarities

Belongs to the peptidase M20A family. DapE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    40,349
  • Last updated
    2014-10-01 v1
  • Checksum
    0A9B82F8A41272AD
MTTDAVALSAELIRCPSVTPEEGGALVLLEALLSKAGFTCTRVDRNGTPNLFARWGAKGAAKSFGFNGHTDVVPVGDAAAWTHDPFGAEIIDGVMWGRGATDMKTAVAAFAAAAVDFVTETPPDGAVILTITGDEEGPGRDGTRALLDWMKDTGEAMSVCLVGEPTCPNEMGEMMKIGRRGSMTFYIEAEGVQGHAAYPHRAKNPLHALVDLLGRMTAEPLDQGTEHFQPSTLQITTIDCGNPANNVIPAKARATVNIRFNDAHSGESLIAWAEAMALAVTMETGITFALNPDISGESFVTPPSPFVDLVARSVEAETGRAPELSTSGGTSDARFVKDHCPVVEFGLVGATMHQVDERVPVDQIETLTRIYARILKDYFA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AUND01000012
EMBL· GenBank· DDBJ
KEO54151.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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