A0A072PJD6 · A0A072PJD6_9EURO

Function

function

Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

tRNA modification; wybutosine-tRNA(Phe) biosynthesis.

GO annotations

AspectTerm
Molecular FunctiontRNA methyltransferase activity
Biological ProcesstRNA methylation
Biological Processwybutosine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA wybutosine-synthesizing protein 4
  • EC number
  • Alternative names
    • Leucine carboxyl methyltransferase 2
    • tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase
    • tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase

Gene names

    • ORF names
      A1O9_08390

Organism names

  • Taxonomic identifier
  • Strain
    • CBS 119918
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Exophiala

Accessions

  • Primary accession
    A0A072PJD6

Proteomes

Organism-specific databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain831-1002JmjC
Compositional bias1055-1107Polar residues
Region1055-1111Disordered

Sequence similarities

Belongs to the methyltransferase superfamily. LCMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,132
  • Mass (Da)
    126,332
  • Last updated
    2014-10-01 v1
  • Checksum
    15A2E1150817C8F5
MASPLNAPVPEPEDELAMEKNAGLIMGTNNSSIVSKRSVEKLYLPQPHFYRYFVRKPQRRSPTINRGYWLRMRAIDWVVRQFLERPSEQRKVILNLGCGYDPIPFQWLAQYRDACDNTKFIDIDFKELMLSKREIILNTPKMKDLLSNPTAAAGSDVLLDSEEYAAIGCDLRNLKRLERLLKTVVDIDQCLVLCLAEVSITYMSVDDSDALIGWTTNLSPDVTFCLLEQQSPDRADNPFTATMLKHFAKLGTPLRSVLTYPGCHTQILRFQNAGYTLIEIQNLWELWADPRFLSPTQRMSLDEVEPFDEWEEFALFASHYCLIVAQTGPDPLIPEQPKSRRASIDSFASDMSTRTVSPYRGKSQWFAYTYSQNPEREGRTHHGSAFGVPNEDAIGLFGGIGQQTRLSTTSVYTSADNKDMIMPALPPEDIGARSCHTITTMGNGQNILVGGRASPSAPMRDCWLQTGSKWERIQDLPEPRFRHRAAAVVLPDNKYGIVVFGGRTSATKVAIDVLLWDRQNGWQKLKSLRSDPMPRFGASFVRLGYNHGLLFGGMRHDGVICQGLWRWRLTIRDNVVAGISFKTSTALDTSAGIFPWLARLGASYSVIRNELLLIGGVAKQGCIPKDYEILSILGSFSAFGEYEKEMELRVACVLPKKDPDVPRPFLIGHSTHRTVRETTLIVGGGATCFSFGTYWNQGCWLLYDRESGVSSHWALVKPKSSKALNTPARKEGTIHDPIMVDAIHPCSETDFLTVLRDGKPRLLTGLDLGPCVSLWTSSYLLSKIPPSQNVVVHSATNRTMNFQRKDFTYTTLTFHNFIKILQSNREAHMYLRSLSSNNPTQAPAIFDKDWPSLAGDVHLDYPCLAFIHRNKHSSPLRVSANVNMWLHYDVMANVLFQIRGTRKLILFPPEDIKHLSFPAGSTTSTLDILEPSQHPGREEDQLRPIPDTHPHIAVLRPGEALFIPPLWSHTGTPLPVLPGTPSASSRSAASITTTLADADSDAANSHINVSLNVFFRSLSSAKYPAGRDVYGNRDLAAYEDGRRDLDKIVRRFISSSSSSSTTTTNNNSSNNAAIQSKNRNPSPKKPQENGTTPPPQTASSSSSADKGGIPKALTKAYLERLADELRERADRL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1055-1107Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AMGV01000007
EMBL· GenBank· DDBJ
KEF55640.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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