A0A072PJD6 · A0A072PJD6_9EURO
- ProteintRNA wybutosine-synthesizing protein 4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1132 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Catalytic activity
- 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine37 in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine37 in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H+
RHEA-COMP:11844 + CHEBI:59789 + CHEBI:16526 = RHEA-COMP:11847 CHEBI:73544 Position: 37+ CHEBI:57856 + 2 CHEBI:15378
Pathway
tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | tRNA methyltransferase activity | |
Biological Process | tRNA methylation | |
Biological Process | wybutosine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA wybutosine-synthesizing protein 4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Exophiala
Accessions
- Primary accessionA0A072PJD6
Proteomes
Organism-specific databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 831-1002 | JmjC | |||
Compositional bias | 1055-1107 | Polar residues | |||
Region | 1055-1111 | Disordered | |||
Sequence similarities
Belongs to the methyltransferase superfamily. LCMT family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,132
- Mass (Da)126,332
- Last updated2014-10-01 v1
- Checksum15A2E1150817C8F5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1055-1107 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AMGV01000007 EMBL· GenBank· DDBJ | KEF55640.1 EMBL· GenBank· DDBJ | Genomic DNA |