A0A069DAE9 · A0A069DAE9_9BACL

  • Protein
    6-phosphogluconate dehydrogenase, decarboxylating
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site10-15NADP+ (UniProtKB | ChEBI)
Binding site33-35NADP+ (UniProtKB | ChEBI)
Binding site74-76NADP+ (UniProtKB | ChEBI)
Binding site102NADP+ (UniProtKB | ChEBI)
Binding site102substrate; ligand shared between dimeric partners; in other chain
Binding site128-130substrate; ligand shared between dimeric partners; in other chain
Active site182Proton acceptor
Binding site185-186substrate; ligand shared between dimeric partners; in other chain
Active site189Proton donor
Binding site190substrate; ligand shared between dimeric partners; in other chain
Binding site260substrate; ligand shared between dimeric partners; in other chain
Binding site287substrate; ligand shared between dimeric partners; in other chain
Binding site446substrate; ligand shared between dimeric partners
Binding site452substrate; ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate catabolic process
Biological Processpentose-phosphate shunt, oxidative branch

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Gene names

    • ORF names
      TCA2_2242

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TCA20
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus

Accessions

  • Primary accession
    A0A069DAE9

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain178-4686-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    470
  • Mass (Da)
    51,766
  • Last updated
    2014-10-01 v1
  • Checksum
    ABD2E82E29EC1136
MAKQQIGVIGLAVMGKNLALNIESKGFSVSVFNRSPEKTQDLLKEADGKNLVGTFSIEEFVQSLESPRKILIMVQAGPATDATIEQLVPHLDQGDIIIDGGNAYFPDTQRRSKELEEKGFRFIGAGVSGGEEGALKGPSIMPGGQESAYELVKPILTSIAAQVNGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLIGEAYHLLKDVLGLNAEQFHEIFSEWNKGELDSYLIEITADIFSKYDEETGKPMVDVILDAAGQKGTGKWTSQSALDLGVPLSMITESVFSRFLSAMKEERIAASKVLSGPKTEAFTGDKAEFIENVRKALFASKIVSYAQGFAQMRAASDEYGWNLKYGNIAMIFRGGCIIRSQFLQNIKDAYDKDAELKNLLLDPYFKNVVESYQDAWRKVISVAVANGIPVPGFASALSYYDSYRTERLPANLLQAQRDYFGAHTFKRVDKEGTFHYNWMGN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BBIW01000003
EMBL· GenBank· DDBJ
GAK39753.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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