A0A069DAE9 · A0A069DAE9_9BACL
- Protein6-phosphogluconate dehydrogenase, decarboxylating
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids470 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalytic activity
- 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10-15 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 33-35 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 74-76 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 102 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 102 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 128-130 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 182 | Proton acceptor | |||
Binding site | 185-186 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 189 | Proton donor | |||
Binding site | 190 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 260 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 287 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 446 | substrate; ligand shared between dimeric partners | |||
Binding site | 452 | substrate; ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | phosphogluconate dehydrogenase (decarboxylating) activity | |
Biological Process | D-gluconate catabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-phosphogluconate dehydrogenase, decarboxylating
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus
Accessions
- Primary accessionA0A069DAE9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 178-468 | 6-phosphogluconate dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the 6-phosphogluconate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length470
- Mass (Da)51,766
- Last updated2014-10-01 v1
- ChecksumABD2E82E29EC1136
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BBIW01000003 EMBL· GenBank· DDBJ | GAK39753.1 EMBL· GenBank· DDBJ | Genomic DNA |