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A0A068MVE1 · A0A068MVE1_SYNY4

Function

function

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site98FMN (UniProtKB | ChEBI)
Active site128Proton donor
Binding site167FMN (UniProtKB | ChEBI)
Binding site197FMN (UniProtKB | ChEBI)
Binding site252-253FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionRNA binding
Molecular FunctiontRNA dihydrouridine synthase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-dihydrouridine synthase
  • EC number

Gene names

    • Name
      dus
    • ORF names
      D082_06190

Organism names

Accessions

  • Primary accession
    A0A068MVE1

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain42-344DUS-like FMN-binding

Sequence similarities

Belongs to the dus family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    348
  • Mass (Da)
    38,427
  • Last updated
    2014-10-01 v1
  • MD5 Checksum
    226802B4C7A6E67CB78EA1117A49F481
MLELRTLKTLSHNSLPNITSAPTVWAKPLQIGSLTLHSRVLQSPLSGVTDLVFRRLVRRYAPHSMLYTEMVSATEIHHLRTLPQVMEIDPQENPISIQLFDCRPDFMAEAAQKAAAQGAQSVDINMGCPVNKITKKGGGSSLLRQPAVAEAIVKTVVAAVDVPVTVKTRLGWDDGEINIIEFAQRLQDAGAQMLTLHGRTRAQGYKGQARWEWIAKVKQALTIPVIANGDIFSVEAAIACLEQTGADGVMCSRGSLGYPFLVGEIEHFFKTGEKLKALTVADRLTCAQEHLQMLWEHKGQRGLFQARKHLAWYCKDFPGAVALREQIFQVNSVQEGKDILDKAINSLQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP007542
EMBL· GenBank· DDBJ
AIE73148.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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