A0A067ZPY5 · A0A067ZPY5_WNV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3433 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1556 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1580 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1640 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2584 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2614 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2615 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2632 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2633 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2659 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2660 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2748 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2968 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2972 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2977 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2980 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3245 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3261 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3380 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus nilense
- Virus hosts
Accessions
- Primary accessionA0A067ZPY5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 44-66 | Helical | ||||
Sequence: IRFVLALLAFFRFTAIAPTRAVL | ||||||
Transmembrane | 107-126 | Helical | ||||
Sequence: GKTGIAVMIGLIASVGAVTL | ||||||
Transmembrane | 250-269 | Helical | ||||
Sequence: WILRNPGYALVAAVIGWMLG | ||||||
Transmembrane | 276-292 | Helical | ||||
Sequence: VVFVVLLLLVAPAYSFN | ||||||
Transmembrane | 743-764 | Helical | ||||
Sequence: LFGGMSWITQGLLGALLLWMGI | ||||||
Transmembrane | 1179-1197 | Helical | ||||
Sequence: AILIALLVLVFGGITYTDV | ||||||
Transmembrane | 1217-1238 | Helical | ||||
Sequence: VVHLALMATFKIQPVFMVASFL | ||||||
Transmembrane | 1245-1261 | Helical | ||||
Sequence: QENILLMLAAVFFQMAY | ||||||
Transmembrane | 1281-1305 | Helical | ||||
Sequence: VAWMILRAITFTTTSNVVVPLLALL | ||||||
Transmembrane | 1312-1330 | Helical | ||||
Sequence: LNLDVYRILLLMVGIGSLI | ||||||
Transmembrane | 1342-1366 | Helical | ||||
Sequence: GASLLCLALASTGLFNPMILAAGLI | ||||||
Transmembrane | 1378-1396 | Helical | ||||
Sequence: ATEVMTAVGLMFAIVGGLA | ||||||
Transmembrane | 1402-1420 | Helical | ||||
Sequence: SMAIPMTIAGLMFAAFVIS | ||||||
Transmembrane | 1472-1498 | Helical | ||||
Sequence: WMLRMVCLAISAYTPWAILPSVVGFWI | ||||||
Transmembrane | 2174-2195 | Helical | ||||
Sequence: ALQTIALIALLSVMTMGVFFLL | ||||||
Transmembrane | 2204-2222 | Helical | ||||
Sequence: IGLGGAVLGVATFFCWMAE | ||||||
Transmembrane | 2228-2245 | Helical | ||||
Sequence: IAGMLLLSLLLMIVLIPE | ||||||
Transmembrane | 2257-2279 | Helical | ||||
Sequence: LAVFLICVMTLVSAVAANEMGWL | ||||||
Transmembrane | 2312-2329 | Helical | ||||
Sequence: ATAWSLYAVTTAVLTPLL | ||||||
Transmembrane | 2350-2373 | Helical | ||||
Sequence: SALFTLSRGFPFVDVGVSALLLAA | ||||||
Transmembrane | 2379-2398 | Helical | ||||
Sequence: VTLTVTVTAATLLFCHYAYM | ||||||
Transmembrane | 2446-2465 | Helical | ||||
Sequence: VGQIMLILVSLAAVVVNPSV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 293↔320 | |||||
Sequence: CLGMSNRDFLEGVSGATWVDLVLEGDSC | ||||||
Disulfide bond | 350↔406 | |||||
Sequence: CYLATVSDLSTKAACPTMGEAHNDKRADPAFVCRQGVVDRGWGNGCGLFGKGSIDTC | ||||||
Disulfide bond | 364↔395 | |||||
Sequence: CPTMGEAHNDKRADPAFVCRQGVVDRGWGNGC | ||||||
Disulfide bond | 382↔411 | |||||
Sequence: CRQGVVDRGWGNGCGLFGKGSIDTCAKFAC | ||||||
Disulfide bond | 480↔578 | |||||
Sequence: CEPRSGIDTNAYYVMTVGTKTFLVHREWFMDLNLPWSSAGSTVWRNRETLMEFEEPHATKQSVIALGSQEGALHQALAGAIPVEFSSNTVKLTSGHLKC | ||||||
Disulfide bond | 595↔626 | |||||
Sequence: CSKAFKFLGTPADTGHGTVVLELQYTGTDGPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1375-1506 | Flavivirus NS2B | ||||
Sequence: GWPATEVMTAVGLMFAIVGGLAELDIDSMAIPMTIAGLMFAAFVISGKSTDMWIERTADISWESDAEITGSSERVDVRLDDDGNFQLMNDPGAPWKIWMLRMVCLAISAYTPWAILPSVVGFWITLQYTKRG | ||||||
Domain | 1506-1683 | Peptidase S7 | ||||
Sequence: GGVLWDTPSPKEYKKGDTTTGVYRIMTRGLLGSYQAGAGVMVEGVFHTLWHTTKGAALMSGEGRLDPYWGSVKEDRLCYGGPWKLQHKWNGQDEVQMIVVEPGKNVKNVQTKPGVFKTPEGEIGAVTLDFPTGTSGSPIVDKNGDVIGLYGNGVIMPNGSYISAIVQGERMDEPIPAG | ||||||
Domain | 1686-1842 | Helicase ATP-binding | ||||
Sequence: PEMLRKKQITVLDLHPGAGKTRRILPQIIKEAINRRLRTAVLAPTRVVAAEMAEALRGLPIRYQTSAVPREHNGNEIVDVMCHATLTHRLMSPHRVPNYNLFVMDEAHFTDPASIAARGYISTKVELGEAAAIFMTATPPGTSDPFPESNSPISDLQ | ||||||
Domain | 1853-2018 | Helicase C-terminal | ||||
Sequence: GYEWITEYTGKTVWFVPSVKMGNEIALCLQRAGKKVVQLNRKSYETEYPKCKNDDWDFVITTDISEMGANFKASRVIDSRKSVKPTIITEGEGRVILGEPSAVTAASAAQRRGRIGRNPSQVGDEYCYGGHTNEDDSNFAHWTEARIMLDNINMPNGLIAQFYQPE | ||||||
Domain | 2529-2794 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: GGAKGRTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHARKEGNVTGGHPVSRGTAKLRWLVERRFLEPVGKVIDLGCGRGGWCYYMATQKRVQEVRGYTKGGPGHEEPQLVQSYGWNIVTMKSGVDVFYRPSECCDTLLCDIGESSSSAEVEEHRTIRVLEMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGGGLVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRMEKRTWKGPQYEEDVNLGSGTRA | ||||||
Domain | 3058-3210 | RdRp catalytic | ||||
Sequence: GKIYADDTAGWDTRITRADLENEAKVLELLDGEHRRLARAIIELTYRHKVVKVMRPAADGRTVMDVISREDQRGSGQVVTYALNTFTNLAVQLVRMMEGEGVIGPDDVEKLTKGKGPKVRTWLVENGEERLSRMAVSGDDCVVKPLDDRFATS |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,433
- Mass (Da)381,114
- Last updated2014-10-01 v1
- ChecksumD733F90559970735