A0A067RFI3 · A0A067RFI3_ZOONE

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site30-35ATP (UniProtKB | ChEBI)
Binding site56a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site78-80a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site105-108a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site112CMP (UniProtKB | ChEBI)
Binding site146ATP (UniProtKB | ChEBI)
Binding site153a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site164a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site192ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionCMP kinase activity
Molecular FunctiondCMP kinase activity
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological ProcessCDP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • ORF names
      L798_03339

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Dictyoptera > Blattodea > Blattoidea > Termitoidae > Termopsidae > Zootermopsis

Accessions

  • Primary accession
    A0A067RFI3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region50-80NMPbind

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    212
  • Mass (Da)
    23,529
  • Last updated
    2014-09-03 v1
  • Checksum
    0D6410B2FAC5DE70
MFTRLLNGIRSLAMSSTIKPDVVFVLGAPGAGKGTQCTNIVKEFGFIHLSAGDLLREERNKEGSEYGELIEDNIKHGRIVPVEITCSLIEKAMKKSGSSKFLIDGFPRNQDNLDGWNRQMAANVNLLFVLFFDCPQEVCVSRCLERGAAGSGRSDDNPESLKKRFDTYMNDSVPIIQYYEQQNLVKKVDAGGTPDEVFEAVKAIFQNISPSR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KK852539
EMBL· GenBank· DDBJ
KDR21793.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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