A0A067CK78 · A0A067CK78_SAPPC

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      SPRG_04277

Organism names

Accessions

  • Primary accession
    A0A067CK78

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane49-69Helical
Transmembrane81-100Helical
Transmembrane174-193Helical
Transmembrane236-253Helical
Transmembrane359-380Helical
Transmembrane387-409Helical
Transmembrane415-438Helical
Transmembrane445-466Helical
Transmembrane478-499Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_500163861126-543Lysosomal dipeptide transporter MFSD1

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    543
  • Mass (Da)
    57,942
  • Last updated
    2014-09-03 v1
  • Checksum
    1E699C842167F9D3
MNDVQRRKPWVLLLACLVDMGNSYCYDTPSALKSQLQEHLHGMPTASFEMAFNLLYTVYSVPNIVLPLLGGLVTDRIGPRSMLVVVTLLILVGHGIFAAGNQLQSVPVMLLGRVVFGLGGETISVAQATVLAVWFESNELALANGFALSTSKLATTLNNELSPVLAEAFGLSSAIWAGVIVCALAFLATLALYQISERSVYDKDDDVRVQLSDVFEFRCDCNPSVTLTSPIPSTTFWLMAGAFFVLYAATGPFNNVASSVFLERDYYKALPTACQRCGLGAYAGDVTCSSLPLTCPPSPPFAHPLPLLSVHCALNQTQCQRVPPYVRAHHINCDAEFWKKGEVTKEYCSVKYAAEQAAAFPLSIAPLLVAATAPLSGYLVDHLGHRAVLATGAMVLLGLSHALIGYTWLSLYVPLVLQGMGFSVFLSALWPAVSYCVAPHHVGTAYGVLCAVLNFGLALVPMLVVIEHNLTGVYVPYVNGMFMVLSLLGVGICATLCVVDHANGGALDGITMTQVQPPPVLLSEVLATEETCLVAVSAVGYGT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KK583199
EMBL· GenBank· DDBJ
KDO31139.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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