A0A067C0H2 · A0A067C0H2_SAPPC

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      SPRG_21161

Organism names

Accessions

  • Primary accession
    A0A067C0H2

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane35-53Helical
Transmembrane74-95Helical
Transmembrane107-126Helical
Transmembrane138-159Helical
Transmembrane205-226Helical
Transmembrane247-268Helical
Transmembrane288-308Helical
Transmembrane315-334Helical
Transmembrane340-363Helical
Transmembrane375-396Helical
Transmembrane402-424Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-428Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    468
  • Mass (Da)
    50,467
  • Last updated
    2014-09-03 v1
  • Checksum
    9CE991D2154B6D92
MSSRASEATGLLQTASRYYGASASWLFWLPTAPSHRFYLLVLICLIPFGGHFVKNEMSSLQQLMIDDKEFPISNTIYGAFNSAVSVPNMIIPFVGGHLLDCKGHVTILYFLILMCLGQALFAYAMQLHSIWLAMAGRIIFGLGEGSVVVGGRAIVAYWFDRSELTFAMGTSVGITNISKMLAKATVAPVALYFGSYRDVKHQVRAGAELVSVVAPSLTWLSSYCYVRRAKKAEVVHEKLSFLAMGSFSPLFWLVVALHVTFINVFHLFQNVSASYFTQVHGYSIVNAGYVSSLAHVFVIFAPLVGLVVDCVGGRIQLILCSSCLSILAYTLLVFTTINPIVPMLMISLCLSVTPTILMASIALSISKHRFGTAFGIVEVVDALGGFVGNLSIGYILDTSGGYNAVMQVLLGLAILTLVLALALAREDARTGNHLAAATIANKNDDVELREADYSTSGSDGGCPEGVYV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KK583266
EMBL· GenBank· DDBJ
KDO22605.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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