A0A066URR1 · A0A066URR1_9VIBR
- ProteinPhosphoheptose isomerase
- GenegmhA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids196 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous
The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Catalytic activity
- 2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 49-51 | substrate | ||||
Sequence: NGG | ||||||
Binding site | 91-92 | substrate | ||||
Sequence: ND | ||||||
Binding site | 117-119 | substrate | ||||
Sequence: STS | ||||||
Binding site | 122 | substrate | ||||
Sequence: S | ||||||
Binding site | 172 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 172 | substrate | ||||
Sequence: H | ||||||
Binding site | 180 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbohydrate derivative binding | |
Molecular Function | D-sedoheptulose 7-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoheptose isomerase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio
Accessions
- Primary accessionA0A066URR1
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-196 | SIS | ||||
Sequence: MVATLLNGNKILCCGNGGSASNAQQFVSCLLNRFETERPSLPAMALTADNTTLTAVANDYHYEEIFSKQVRAFGQTGDILLAISTSGNSKNIIKAMEAAVTRDMTIIAFTGKDGGEMAGLLGEHDVEIRIPSHRTARIHEVHMVTLHCLCDLIDQVLFPAHEE |
Sequence similarities
Belongs to the SIS family. GmhA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length196
- Mass (Da)21,140
- Last updated2014-09-03 v1
- ChecksumBC45A810F37CC269
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VWSE01000008 EMBL· GenBank· DDBJ | KAB0286135.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VXDD01000001 EMBL· GenBank· DDBJ | KAB0304631.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JFFR01000028 EMBL· GenBank· DDBJ | KDN26829.1 EMBL· GenBank· DDBJ | Genomic DNA |