A0A063B3Z3 · A0A063B3Z3_9BURK

  • Protein
    Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ
  • Gene
    msrQ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionelectron transfer activity
Molecular FunctionFMN binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processprotein repair

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ
  • Alternative names
    • Flavocytochrome MsrQ

Gene names

    • Name
      msrQ
    • ORF names
      LIG30_4041

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LIG30
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia

Accessions

  • Primary accession
    A0A063B3Z3

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-51Helical
Transmembrane71-90Helical
Transmembrane102-121Helical
Transmembrane141-162Helical
Transmembrane174-190Helical
Transmembrane202-220Helical

Keywords

Interaction

Subunit

Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-21Disordered
Domain70-184Ferric oxidoreductase

Sequence similarities

Belongs to the MsrQ family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    225
  • Mass (Da)
    25,089
  • Last updated
    2014-09-03 v1
  • Checksum
    DA88C68960705875
MQPSTLTPASGAGAAGRRTGLARPGGAPRWVAPAKAAVFAAGLYPLARLVLFGLTDRLGANPVEFITRSTGLWTLVMLCVTLAVTPLRRMTGINMLLRFRRMLGLFAFFYATLHFTTYFWFDKWFDLMAILADVGKRPFITMGFAAFVLLIPLAATSPRAMVRKLGRHWATLHRAIYAIALFGVLHFWWMKAGKHDLAQPKLYAVIVAVLLGWRLAAWGWRRVRG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JGVW01000099
EMBL· GenBank· DDBJ
KDB06635.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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