A0A062WZN9 · A0A062WZN9_9ACTN

  • Protein
    Phosphatidylinositol phosphate synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Contains a di-nuclear catalytic Mg2+ center.

Pathway

Lipid metabolism.
Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site29-32a CDP-1,2-diacyl-sn-glycerol (UniProtKB | ChEBI)
Binding site66Mg2+ 1 (UniProtKB | ChEBI)
Binding site66Mg2+ 2 (UniProtKB | ChEBI)
Binding site69Mg2+ 1 (UniProtKB | ChEBI)
Binding site70a CDP-1,2-diacyl-sn-glycerol (UniProtKB | ChEBI)
Binding site74a CDP-1,2-diacyl-sn-glycerol (UniProtKB | ChEBI)
Binding site80a CDP-1,2-diacyl-sn-glycerol (UniProtKB | ChEBI)
Binding site87Mg2+ 1 (UniProtKB | ChEBI)
Binding site87Mg2+ 2 (UniProtKB | ChEBI)
Active site91Proton acceptor
Binding site91Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol phosphate synthase
  • EC number
  • Short names
    PIP synthase
  • Alternative names
    • CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase

Gene names

    • ORF names
      BMG523Draft_01062

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • BMG5.23
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Frankiales > Frankiaceae > Frankia

Accessions

  • Primary accession
    A0A062WZN9

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-47Helical
Transmembrane114-134Helical
Transmembrane154-180Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region204-237Disordered
Compositional bias209-237Polar residues

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    237
  • Mass (Da)
    24,770
  • Last updated
    2014-09-03 v1
  • Checksum
    CF501ABD0540DDFD
MLASKARPQIQKLLDPVSQWAARSSVSPDVVTIIGMVGVAGGALGFFTRGVFFLGTVVVTLFVFSDLIDGVIARARGISSKWGAFLDSTSDRVGDGAIFGSLVLWYAGDGDSLPLAGAALICLVAGSITSYVKARAEGLGFTCDVGFAERGERLLILLVAAGLYGLGVPYLLPAALWFLVGATTLTVVQRVVHVYRQWYRAGDPPSPLTSRAAPTTASRTTAASRSATTFGPGRNGR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias209-237Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JDWE01000007
EMBL· GenBank· DDBJ
KDA43968.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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